Impact of vaccination on SARS-CoV-2 transmission in the UK: a modelling study

Nieves Derqui, Swapnil Mishra, Wes R Hinsley, Samir Bhatt, Daniel J Laydon
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Abstract

Background Efficacy and effectiveness of vaccines against SARS-CoV-2 infection, severe disease and death have been widely assessed. However, the impact of vaccination against SARS-CoV-2 transmission is far less well-characterized, and has major implications for public health, because it informs the indirect effects of vaccination in addition to its direct effects. Analysing the effects of SARS-CoV-2 vaccination on transmission is challenging, because they must be considered in tandem with the time-varying reproduction number (Rt), while also accounting for regional variability, for example due to the presence of more transmissible variants.
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疫苗接种对英国 SARS-CoV-2 传播的影响:一项模拟研究
背景 针对 SARS-CoV-2 感染、严重疾病和死亡的疫苗的效力和效果已得到广泛评估。然而,疫苗接种对 SARS-CoV-2 传播的影响却远未得到很好的描述,这对公共卫生有重大影响,因为除了疫苗接种的直接影响外,它还提供了间接影响的信息。分析 SARS-CoV-2 疫苗接种对传播的影响具有挑战性,因为必须将这些影响与随时间变化的繁殖数量 (Rt) 结合起来考虑,同时还要考虑区域变异性,例如由于存在更多可传播的变种。
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