Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset

Cassandra M. Joynes, Murat Bilgel, Yang An, Abhay R. Moghekar, Nicholas J. Ashton, Przemysław R. Kac, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick, Keenan A. Walker
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Abstract

INTRODUCTION The factors that influence the progression of Alzheimer’s disease (AD) after individuals become amyloid-positive are poorly understood. This study examines how sex influences the longitudinal trajectories of plasma AD and neurodegenerative biomarkers in the years following a person’s estimated onset of amyloid-β.
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与淀粉样蛋白发病有关的血浆生物标志物、脑萎缩和认知能力下降轨迹的性别差异
引言 人们对阿尔茨海默病(AD)在淀粉样蛋白阳性后的进展影响因素知之甚少。本研究探讨了在估计淀粉样蛋白-β发病后的数年内,性别如何影响血浆阿尔茨海默病和神经退行性疾病生物标志物的纵向轨迹。
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