Exploring the Diverse Therapeutic Applications of 1, 3-Thiazine: A Comprehensive Review

IF 1.9 4区医学 Q3 CHEMISTRY, MEDICINAL Medicinal Chemistry Pub Date : 2024-09-02 DOI:10.2174/0115734064328915240827062052

Neetu Agrawal, Deepika Goyal, Shilpi Pathak

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Abstract

Thiazine, a six-membered heterocycle containing nitrogen and sulfur atoms, is of paramount importance due to its diverse biological functions and broad therapeutic effects. The pharmacological attributes of 1,3-thiazine span a wide range of activities, including antileukemic, antimycobacterial, anti-inflammatory, sedative, hypnotic, anti-influenza, antituberculosis, melanogenesis inhibition, BACE1 inhibition (with anti-Alzheimer's potential), growth promotion, neuroprotective, and anticonvulsant properties. Consequently, novel synthetic methodologies and the design of new 1,3-thiazine derivatives are significantly influenced by recent research findings. This comprehensive review explores both in vivo and in vitro preclinical studies on the biomedical and therapeutic applications of 1,3-thiazine, highlighting its extensive medical relevance. It is anticipated that derivatization strategies for 1,3-thiazine will open new avenues for the development of innovative biological agents. This review aims to engage researchers, stimulating the creation of promising new treatments and preventive measures for various diseases.

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探索 1，3-噻嗪的多种治疗应用：全面回顾

噻嗪是一种含有氮原子和硫原子的六元杂环，因其具有多种生物功能和广泛的治疗效果而变得极为重要。1,3-thiazine 的药理特性具有广泛的活性，包括抗白血病、抗霉菌、抗炎、镇静、催眠、抗流感、抗结核、黑色素生成抑制、BACE1 抑制（具有抗阿尔茨海默氏症的潜力）、生长促进、神经保护和抗惊厥特性。因此，新的合成方法和新的 1,3-噻嗪衍生物的设计受到近期研究成果的极大影响。本综述探讨了有关 1,3-噻嗪生物医学和治疗应用的体内和体外临床前研究，强调了其广泛的医学相关性。预计 1,3-噻嗪的衍生化策略将为创新生物制剂的开发开辟新途径。这篇综述旨在吸引研究人员的参与，激励他们为各种疾病开发出有前景的新疗法和预防措施。

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来源期刊

Medicinal Chemistry 医学-医药化学

CiteScore

4.30

自引率

4.30%

发文量

109

审稿时长

12 months

期刊介绍： Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.