Egg shell powder mediated Cu catalyst: A biowaste based catalytic approach for the synthesis of quinazolin-4(3H)-ones and propargyl amines

Abstract

A novel and efficient approach for a tandem oxidative synthesis of quinazolin-4(3H)-one from 2-aminobenzonitrile and benzyl alcohol has been unveiled via Cu₂(CO₃)(OH)₂. Herein CuSO_4.5H₂O accompanied by egg shell powder is used for the easy preparation of Cu₂(CO₃)(OH)₂. The reported method portrays a wide range of substrate scope with good to excellent yield and the given reaction proceed at room temperature within 12 h. Single crystal of one of the synthesized quinazolin-4(3H)-ones was analysed through single crystal X-ray diffraction (SC-XRD). Some of the compounds reported here are also known to possess various pharmaceutical activities. Eventually the newly prepared catalyst was applied for propargylamine synthesis via a multi component reaction. Perceiving all the advantages, present protocol is conceivably considered as clean, cost-effective and sustainable over reported procedures used for synthesis of quinazolin-4(3H)-ones and propargyl amines.