{"title":"Visible-Light-Mediated Copper(I)-Catalyzed Regiospecific Amino-Hydroxylation and Amino-Alkoxylation of Vinyl Arenes","authors":"Dhandapani Ganapathy, Baldau Singh, Tiwari Neeraj Brijbhushan, Krishn Kumar, Piyush Pandey","doi":"10.1002/ejoc.202400996","DOIUrl":null,"url":null,"abstract":"Aminohydroxylation of alkene is an important method for synthesizing 1,2-amino alcohols, which are found in natural products, pharmaceutically active compounds and several marketed drugs. Herein, we report the development of visible-light mediated copper-catalyzed aminohydroxylation and aminoalkoxylation of alkenes. In contrast to expensive iridium, ruthenium, or organic-dyes based photocatalysts, this protocol takes advantage of economical copper phenanthroline complex as a photocatalyst for the generation of N-centred radical from N-amino pyridinium salt. Furthermore, this protocol features a mild reaction conditions, broad substrate scope, and regiospecific.","PeriodicalId":167,"journal":{"name":"European Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/ejoc.202400996","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Aminohydroxylation of alkene is an important method for synthesizing 1,2-amino alcohols, which are found in natural products, pharmaceutically active compounds and several marketed drugs. Herein, we report the development of visible-light mediated copper-catalyzed aminohydroxylation and aminoalkoxylation of alkenes. In contrast to expensive iridium, ruthenium, or organic-dyes based photocatalysts, this protocol takes advantage of economical copper phenanthroline complex as a photocatalyst for the generation of N-centred radical from N-amino pyridinium salt. Furthermore, this protocol features a mild reaction conditions, broad substrate scope, and regiospecific.
期刊介绍：
The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.
The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry:
Liebigs Annalen
Bulletin des Sociétés Chimiques Belges
Bulletin de la Société Chimique de France
Gazzetta Chimica Italiana
Recueil des Travaux Chimiques des Pays-Bas
Anales de Química
Chimika Chronika
Revista Portuguesa de Química
ACH—Models in Chemistry
Polish Journal of Chemistry.
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