Identification of oxidative stress biomarkers in apical periodontitis: A scoping review with bibliometric analysis

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Australian Endodontic Journal Pub Date : 2024-09-19 DOI:10.1111/aej.12888

Nara Sarmento Macedo Signorelli, Sávio Gabriel Silva Rende, Eugenio Luigi Iorio, Danilo Cassiano Ferraz, Luiz Renato Paranhos, Camilla Christian Gomes Moura

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Abstract

Oxidative stress (OS) is a ubiquitous process for protecting against microorganisms' challenges. This review maps the most used methods for obtaining samples and analysing reactive oxygen species levels in apical periodontitis, following the PRISMA Extension for Scoping Reviews and is registered in Open Science Framework ([https://doi.org/10.17605/OSF.IO/D5U76]). A systematic search was conducted in electronic databases MEDLINE (PubMed), Embase, Scopus, Web of Science, LILACS, SciElo, OATD and DANS up to 17 July 2023. A total of 18 studies were included, with periapical tissue being the most common sample. Twenty-eight different oxidative stress markers were identified, with inducible nitric oxide synthase being the most prevalent. The use of diverse biomarkers for oxidative stress assessment lacks specificity in identifying particular OS species for evaluating apical periodontitis and potential systemic effects. Studies are necessary to compare results obtained from less invasive methods (such as saliva and crevicular fluid) with those from periapical lesion samples.

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根尖牙周炎中氧化应激生物标志物的鉴定：范围综述与文献计量分析

氧化应激（OS）是抵御微生物挑战的一个无处不在的过程。本综述按照《范围界定综述的 PRISMA 扩展》（PRISMA Extension for Scoping Reviews）的要求，介绍了牙根尖周炎中获取样本和分析活性氧水平的最常用方法，并在开放科学框架（[https://doi.org/10.17605/OSF.IO/D5U76]）中进行了注册。截至 2023 年 7 月 17 日，在 MEDLINE (PubMed)、Embase、Scopus、Web of Science、LILACS、SciElo、OATD 和 DANS 等电子数据库中进行了系统检索。共纳入 18 项研究，其中根尖周组织是最常见的样本。研究发现了 28 种不同的氧化应激标记物，其中以诱导型一氧化氮合酶最为普遍。使用不同的生物标记物评估氧化应激缺乏特异性，无法确定特定的 OS 种类来评估根尖牙周炎和潜在的全身影响。有必要进行研究，将侵入性较小的方法（如唾液和缝隙液）与根尖周病变样本的结果进行比较。

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.