Advances in microbial production of geraniol: from metabolic engineering to potential industrial applications.

IF 8.1 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Biotechnology Pub Date : 2024-09-12 DOI:10.1080/07388551.2024.2391881
Xun Wang,Xinyi Zhang,Jia Zhang,Yujunjie Zhou,Fei Wang,Zhiguo Wang,Xun Li
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引用次数: 0

Abstract

Geraniol, an acyclic monoterpene alcohol, has significant potential applications in various fields, including: food, cosmetics, biofuels, and pharmaceuticals. However, the current sources of geraniol mainly include plant tissue extraction or chemical synthesis, which are unsustainable and suffer severely from high energy consumption and severe environmental problems. The process of microbial production of geraniol has recently undergone vigorous development. Particularly, the sustainable construction of recombinant Escherichia coli (13.2 g/L) and Saccharomyces cerevisiae (5.5 g/L) laid a solid foundation for the microbial production of geraniol. In this review, recent advances in the development of geraniol-producing strains, including: metabolic pathway construction, key enzyme improvement, genetic modification strategies, and cytotoxicity alleviation, are critically summarized. Furthermore, the key challenges in scaling up geraniol production and future perspectives for the development of robust geraniol-producing strains are suggested. This review provides theoretical guidance for the industrial production of geraniol using microbial cell factories.
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微生物生产香叶醇的进展:从代谢工程到潜在的工业应用。
香叶醇是一种无环单萜醇,在食品、化妆品、生物燃料和制药等多个领域都有重要的潜在应用。然而,目前的香叶醇来源主要包括植物组织提取或化学合成,这两种方法都是不可持续的,而且存在严重的高能耗和严重的环境问题。近年来,微生物生产香叶醇的工艺得到了蓬勃发展。特别是重组大肠杆菌(13.2 克/升)和酿酒酵母(5.5 克/升)的可持续构建为香叶醇的微生物生产奠定了坚实的基础。在这篇综述中,对最近在开发香叶醇生产菌株方面取得的进展进行了批判性总结,包括:代谢途径构建、关键酶改良、基因修饰策略和细胞毒性缓解。此外,还提出了扩大香叶醇生产规模所面临的主要挑战,以及开发稳健的香叶醇生产菌株的未来前景。本综述为利用微生物细胞工厂进行香叶醇的工业化生产提供了理论指导。
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来源期刊
Critical Reviews in Biotechnology
Critical Reviews in Biotechnology 工程技术-生物工程与应用微生物
CiteScore
20.80
自引率
1.10%
发文量
71
审稿时长
4.8 months
期刊介绍: Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.
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