Electrophoresis of polyelectrolyte‐adsorbed soft particle with hydrophobic inner core

IF 3 3区生物学 Q2 BIOCHEMICAL RESEARCH METHODS ELECTROPHORESIS Pub Date : 2024-09-17 DOI:10.1002/elps.202400143

Asim Mahata, Sanjib Kumar Pal, Hiroyuki Ohshima, Partha P. Gopmandal

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Abstract

This article deals with the electrophoresis of hydrophobic colloids absorbed by a layer of polymers with an exponential distribution of the polymer segments. The functional groups present in the polymer layer further follow the exponential distribution. We made an extensive mathematical study of the electrophoresis of such core‐shell structured soft particles considering the combined impact of heterogeneity in polymer segment distribution, ion steric effect, and hydrodynamic slippage of the inner core. The mathematical model is based on the flat‐plate formalism and deduced numerical results for electrophoretic mobility are valid for weak to highly charged particles for which the particle size well exceeds the Debye‐layer thickness. In addition, we have derived closed form analytical results for electrophoretic mobility of the particle under several electrohydrodynamic limits. We have further illustrated the results for electrophoretic mobility considering a charged and hydrophobic inner core coated with an uncharged polymer layer or a polymer layer that entraps either positive or negatively charged functional groups. The impact of pertinent parameters on the overall electrophoretic motion is further illustrated.

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具有疏水内核的聚电解质吸附软颗粒的电泳技术

本文论述了被聚合物层吸收的疏水性胶体的电泳问题，聚合物段呈指数分布。聚合物层中的官能团进一步遵循指数分布。考虑到聚合物段分布的异质性、离子立体效应和内核的流体动力滑动的综合影响，我们对这种核壳结构软粒子的电泳进行了广泛的数学研究。数学模型基于平板形式主义，推导出的电泳流动性数值结果适用于粒径远大于德拜层厚度的弱电荷到高电荷颗粒。此外，我们还推导出了颗粒在几种电流体力学限制条件下的电泳迁移率的封闭式分析结果。考虑到带电和疏水的内核涂有不带电的聚合物层或夹带正电或负电官能团的聚合物层，我们进一步说明了电泳迁移率的结果。进一步说明了相关参数对整体电泳运动的影响。

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来源期刊

ELECTROPHORESIS 生物-分析化学

CiteScore

6.30

自引率

13.80%

发文量

244

审稿时长

1.9 months

期刊介绍： ELECTROPHORESIS is an international journal that publishes original manuscripts on all aspects of electrophoresis, and liquid phase separations (e.g., HPLC, micro- and nano-LC, UHPLC, micro- and nano-fluidics, liquid-phase micro-extractions, etc.). Topics include new or improved analytical and preparative methods, sample preparation, development of theory, and innovative applications of electrophoretic and liquid phase separations methods in the study of nucleic acids, proteins, carbohydrates natural products, pharmaceuticals, food analysis, environmental species and other compounds of importance to the life sciences. Papers in the areas of microfluidics and proteomics, which are not limited to electrophoresis-based methods, will also be accepted for publication. Contributions focused on hyphenated and omics techniques are also of interest. Proteomics is within the scope, if related to its fundamentals and new technical approaches. Proteomics applications are only considered in particular cases. Papers describing the application of standard electrophoretic methods will not be considered. Papers on nanoanalysis intended for publication in ELECTROPHORESIS should focus on one or more of the following topics: • Nanoscale electrokinetics and phenomena related to electric double layer and/or confinement in nano-sized geometry • Single cell and subcellular analysis • Nanosensors and ultrasensitive detection aspects (e.g., involving quantum dots, "nanoelectrodes" or nanospray MS) • Nanoscale/nanopore DNA sequencing (next generation sequencing) • Micro- and nanoscale sample preparation • Nanoparticles and cells analyses by dielectrophoresis • Separation-based analysis using nanoparticles, nanotubes and nanowires.