{"title":"Facile Synthesis of Diverse 1,3,5-Trisubstituted 1,2,4-Triazole using Hydrazones with Aldehydes, Alkenes, Amines","authors":"Yi Liu, Kunyi Zhang, Jialiang Zhang, Shuaikun Liu, Yu Song, Xinqiang Tan, Lizhen Fang","doi":"10.1002/ajoc.202400424","DOIUrl":null,"url":null,"abstract":"An efficient, and easy method for the synthesis of 1,3,5- substituted 1,2,4-triazole derivatives by [3+2] annulation reactions of hydrazones with aldehydes, alkenes, or amines has been established. This strategy is characterized by the use of inexpensive and readily available oxidants and starting materials, a broader substrate scope, and moderate to good yields.","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/ajoc.202400424","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
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Abstract
An efficient, and easy method for the synthesis of 1,3,5- substituted 1,2,4-triazole derivatives by [3+2] annulation reactions of hydrazones with aldehydes, alkenes, or amines has been established. This strategy is characterized by the use of inexpensive and readily available oxidants and starting materials, a broader substrate scope, and moderate to good yields.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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