Risk of depression in patients with atopic dermatitis: An updated systematic review and meta-analysis of children, adolescent and adult groups

IF 1.6 4区医学 Q2 PEDIATRICS Journal of paediatrics and child health Pub Date : 2024-09-17 DOI:10.1111/jpc.16668

Lihua Cao, Jiangwei Su, Fang Tian, Yang Zhou, Songchun Liu, Fanglu Lou

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Abstract

Aim

Atopic dermatitis is a popular allergy disease among children, adolescents and adults. The risk of depression in patients with atopic dermatitis can be evaluated using an updated systemic review and meta-analysis of observational and cross-sectional studies.

Methods

The log odds ratio (OR) was transformed using the OR and 95% confidence interval (CI) to assess the risk of depression in patients with atopic dermatitis across the children, adolescent and adult groups. After a restricted selection, 39 studies of 234 306 patients with atopic dermatitis and 10 935 459 reference individuals were enrolled. The focused outcome was the OR and 95% CI of depression risk in each included study, assigned according to the age for the children, adolescent and adult groups.

Results

In adult patients with atopic dermatitis, a significantly higher risk of depression was observed. In addition, the similar significantly higher risk of depression was observed in children and adolescent patients with atopic dermatitis, respectively. However, the significantly high heterogeneity was observed across children, adolescent and adult groups.

Conclusions

In the current meta-analysis, the patients with atopic dermatitis had a higher risk of depression across the children, adolescent and adult groups, respectively. However, substantial heterogeneity should be considered during the interpretation of our meta-analysis results.

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特应性皮炎患者患抑郁症的风险：针对儿童、青少年和成人群体的最新系统综述和荟萃分析

目的特应性皮炎是儿童、青少年和成人中常见的过敏性疾病。通过对观察性研究和横断面研究进行最新的系统回顾和荟萃分析，可以评估特应性皮炎患者患抑郁症的风险。方法使用OR和95%置信区间（CI）转换对数赔率（OR），评估儿童、青少年和成人特应性皮炎患者患抑郁症的风险。经过筛选，39 项研究共纳入了 234 306 名特应性皮炎患者和 10 935 459 名参照个体。重点结果是每项纳入研究的抑郁风险 OR 和 95% CI，根据儿童、青少年和成人组的年龄进行分配。此外，在儿童和青少年特应性皮炎患者中也分别观察到了类似的明显较高的抑郁风险。结论在当前的荟萃分析中，异位性皮炎患者在儿童、青少年和成人组中的抑郁风险都较高。然而，在解释我们的荟萃分析结果时应考虑到严重的异质性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of paediatrics and child health 医学-小儿科

CiteScore

2.90

自引率

5.90%

发文量

487

审稿时长

3-6 weeks

期刊介绍： The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.