Acid-activatable photosensitizers for photodynamic therapy using self-aggregates of chlorophyll‒peptide conjugates

IF 2.3 4区 化学 Q3 POLYMER SCIENCE Polymer Journal Pub Date : 2024-09-19 DOI:10.1038/s41428-024-00961-2
Miyu Nagatani, Masaru Yoshikawa, Shinya Tsukiji, Masahiro Higuchi, Hitoshi Tamiaki, Shogo Matsubara
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Abstract

Photodynamic therapy is useful due to its high antitumor efficacy, spatiotemporal selectivity, and noninvasiveness and has garnered significant attention in the field of cancer treatment. When photoexcited by light irradiation, photosensitizers produce reactive oxygen species (ROS) that damage tumor tissues. However, photosensitizers can also accumulate in normal tissues, leading to side effects such as skin photosensitivity. To mitigate these side effects, we report the development of chlorophyll‒peptide conjugates as tumor-selective photosensitizers. These conjugates bearing histidine and lysine residues self-assemble into nanoparticles that are expected to accumulate selectively in tumors and reduce ROS generation through self-quenching under the neutral conditions typical of normal tissues. In contrast, these aggregated conjugates partially disassemble under weakly acidic conditions, such as those found in tumor tissues, resulting in phototoxicity. We anticipate that these acid-activatable conjugates have the potential to serve as cancer-selective photosensitizers, thereby reducing phototoxicity in normal tissues.

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利用叶绿素-肽共轭物的自聚集体开发可酸激活的光敏剂,用于光动力疗法
光动力疗法具有抗肿瘤疗效高、时空选择性强、无创伤等优点,在癌症治疗领域备受关注。光敏剂在光照射下受到光激发时,会产生活性氧(ROS),从而破坏肿瘤组织。然而,光敏剂也会在正常组织中积聚,导致皮肤光敏等副作用。为了减轻这些副作用,我们报告了叶绿素-肽共轭物作为肿瘤选择性光敏剂的开发情况。这些带有组氨酸和赖氨酸残基的共轭物可自组装成纳米颗粒,在正常组织典型的中性条件下,有望选择性地聚集在肿瘤中,并通过自淬灭减少 ROS 的产生。相反,这些聚集的共轭物在弱酸性条件下(如肿瘤组织中的弱酸性条件)会部分解聚,从而产生光毒性。我们预计这些可被酸激活的共轭物有可能成为癌症选择性光敏剂,从而减少正常组织的光毒性。
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来源期刊
Polymer Journal
Polymer Journal 化学-高分子科学
CiteScore
5.60
自引率
7.10%
发文量
131
审稿时长
2.5 months
期刊介绍: Polymer Journal promotes research from all aspects of polymer science from anywhere in the world and aims to provide an integrated platform for scientific communication that assists the advancement of polymer science and related fields. The journal publishes Original Articles, Notes, Short Communications and Reviews. Subject areas and topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Polymer synthesis and reactions Polymer structures Physical properties of polymers Polymer surface and interfaces Functional polymers Supramolecular polymers Self-assembled materials Biopolymers and bio-related polymer materials Polymer engineering.
期刊最新文献
Special issue: Rising Stars in Polymer Science 2024 Effect of heat treatment time on the PTC behavior of wollastonite/CB/CPE composites Acid-activatable photosensitizers for photodynamic therapy using self-aggregates of chlorophyll‒peptide conjugates Viscoelastic behaviors for optimizing self-healing of gels with host–guest inclusion complexes Structural analysis of polymers via solid-state dynamic nuclear polarization (DNP)-NMR
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