O. N. Grebyonkina, O. A. Banina, R. V. Rumyantsev, D. R. Baidamshina, A. I. Kolesnikova, O. M. Lezina, S. A. Rubtsova
{"title":"Synthesis of new chiral arylsulfonamides based on carane amino alcohols","authors":"O. N. Grebyonkina, O. A. Banina, R. V. Rumyantsev, D. R. Baidamshina, A. I. Kolesnikova, O. M. Lezina, S. A. Rubtsova","doi":"10.1007/s11172-024-4345-0","DOIUrl":null,"url":null,"abstract":"<p>New optically active arylsulfonamides, including carane-containing streptocide analogs, were synthesized by the reaction of carane amino alcohols with tosyl- and <i>N</i>-acetylsulfanilyl chlorides. Sulfonamide, which was prepared based on (–)-4β-amino-3α-hydroxy-<i>cis</i>-carane, was studied by X-ray diffraction. The synthesized sulfonamides and the starting amino alcohols were evaluated for antimicrobial activity.</p>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Chemical Bulletin","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s11172-024-4345-0","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
New optically active arylsulfonamides, including carane-containing streptocide analogs, were synthesized by the reaction of carane amino alcohols with tosyl- and N-acetylsulfanilyl chlorides. Sulfonamide, which was prepared based on (–)-4β-amino-3α-hydroxy-cis-carane, was studied by X-ray diffraction. The synthesized sulfonamides and the starting amino alcohols were evaluated for antimicrobial activity.
期刊介绍：
Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections:
General and Inorganic Chemistry;
Physical Chemistry;
Organic Chemistry;
Organometallic Chemistry;
Chemistry of Natural Compounds and Bioorganic Chemistry.
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