Low Concentrations of Wyethia Helenioides-derived Flavonoids as Anti-Inflammatory Against Allergic Rhinitis.

Abstract

Context: Allergic rhinitis (AR) is a common immune disease of the nasal mucosa, and anti-allergenic medications provide only momentary relief. Multiple factors, such as rising pollution, especially in urban areas; dust particles, such as from air conditioners; house mites; and the use of chemicals and aromatic products can stimulate AR.

Objective: The literature review intended to examine the effectiveness of homoeopathic remedies in immune- and inflammatory-model systems based on the basic homoeopathic principle-the law of similarity of pharmacological action at the cellular level-and to evaluate the effects of dilution or dynamization on the drug activity of Wyethia tested under controlled settings, interpreting data based on similarity.

Design: The research team performeda narrative review by searching Google scholar & Pubmed databases. The search usedthe keywords "Wyethia Helenioides", "Allergic Rhinitis", "Homoeopathy", "Homeopathy", "Anti-inflammatory", "Invitro", "Invivo", "Clinical Trial", "Case report" & "Flavanoids".

Setting: The study took place at Department of Homoeopathic Materia Medica, Dr. D Y Patil Homoeopathic Medical College and Research Institute, Pimpri, Pune, Maharashtra, India.

Results: Clinical observations indicated that the homoeopathic preparations of Wyethia in low concentrations, even beyond Avogadro's number, may have antimicrobial, antioxidant, and anti-inflammatory properties. The hormesis concept-a biphasic dose response with a low-dose stimulation or beneficial effect and a high dose inhibitory or toxic effect-may explain the effects against human mast cells(HMC-1s).

Conclusions: Clinical observations indicate that the homoeopathic preparations of Wyethia in low concentrations, even beyond Avogadro's number, might show anti-inflammatory properties that the hormesis concept against HMC-1 can explain. The current research team thus anticipates that the analysis of this little-known material will provide a novel and insightful look at the state-of-the-art of homoeopathy without drawing any firm judgments for or against this treatment. Although it could be challenging to accept, it's currently the most receptive stance.