Lupeol: A dietary and medicinal triterpene with therapeutic potential

IF 5.3 2区 医学 Q1 PHARMACOLOGY & PHARMACY Biochemical pharmacology Pub Date : 2024-09-16 DOI:10.1016/j.bcp.2024.116545
Koushik Sen , Sanjib Kumar Das , Nabanita Ghosh , Krishnendu Sinha , Parames C. Sil
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Abstract

Lupeol, a triterpene derived from various plants, has emerged as a potent dietary supplement with extensive therapeutic potential. This review offers a comprehensive examination of lupeol’s applications across diverse health conditions. By meticulously analyzing current scientific literature, we have synthesized findings that underscore lupeol’s impact on cancer, diabetes, gastrointestinal disorders, neurological diseases, dermatological conditions, nephrological issues, and cardiovascular health. The review delves into molecular studies that reveal lupeol’s ability to modulate disease pathways and alleviate symptoms, positioning it as a promising therapeutic agent. Moreover, we discuss the potential role of lupeol in clinical practice and public health strategies, emphasizing its substantial benefits as a natural compound. This thorough analysis serves as a critical resource for researchers, providing insights into the multifaceted therapeutic properties of lupeol and its potential to significantly enhance health outcomes.

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羽扇豆醇:一种具有治疗潜力的膳食和药用三萜。
羽扇豆醇是从多种植物中提取的一种三萜类化合物,是一种具有广泛治疗潜力的强效膳食补充剂。本综述全面探讨了羽扇豆醇在各种健康状况下的应用。通过对当前科学文献的细致分析,我们总结出了羽扇豆醇对癌症、糖尿病、胃肠道疾病、神经系统疾病、皮肤病、肾病和心血管健康的影响。这篇综述深入探讨了分子研究,揭示了羽扇豆醇调节疾病途径和缓解症状的能力,并将其定位为一种前景广阔的治疗药物。此外,我们还讨论了羽扇豆醇在临床实践和公共卫生战略中的潜在作用,强调了它作为天然化合物的巨大益处。这份详尽的分析报告为研究人员提供了重要资源,让他们深入了解羽扇豆醇的多方面治疗特性及其显著改善健康状况的潜力。
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来源期刊
Biochemical pharmacology
Biochemical pharmacology 医学-药学
CiteScore
10.30
自引率
1.70%
发文量
420
审稿时长
17 days
期刊介绍: Biochemical Pharmacology publishes original research findings, Commentaries and review articles related to the elucidation of cellular and tissue function(s) at the biochemical and molecular levels, the modification of cellular phenotype(s) by genetic, transcriptional/translational or drug/compound-induced modifications, as well as the pharmacodynamics and pharmacokinetics of xenobiotics and drugs, the latter including both small molecules and biologics. The journal''s target audience includes scientists engaged in the identification and study of the mechanisms of action of xenobiotics, biologics and drugs and in the drug discovery and development process. All areas of cellular biology and cellular, tissue/organ and whole animal pharmacology fall within the scope of the journal. Drug classes covered include anti-infectives, anti-inflammatory agents, chemotherapeutics, cardiovascular, endocrinological, immunological, metabolic, neurological and psychiatric drugs, as well as research on drug metabolism and kinetics. While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Submissions describing work focused predominately on chemical synthesis and molecular modeling will not be considered for review. While particular emphasis is placed on reporting the results of molecular and biochemical studies, research involving the use of tissue and animal models of human pathophysiology and toxicology is of interest to the extent that it helps define drug mechanisms of action, safety and efficacy.
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