Evaluation of Serum Adipokine Levels in Girls With Central Precocious Puberty.

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Clinical Endocrinology Pub Date : 2024-09-16 DOI:10.1111/cen.15132
Ilkin Seda Can Caglayan, Nurullah Çelik, Serkan Bolat
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Abstract

Purpose: Adipose tissue has an important endocrine function by secreting a variety of hormones known as adipokines, such as Visfatin, Omentin-1 and Chemerin. On the other hand, these hormones are also secreted from places other than fatty tissues in the girl's genital system. The goal of this study was to demonstrate the secretory status of adipokines in patients with central precocious puberty (CPP) and their utility in the diagnosis of precocious puberty.

Method: A total of 105 patients were included in the study (53 in the CPP group and 52 in the control group). The following were used as the CPP diagnostic criteria; breast development, basal LH measurement higher than 0.3 IU/L, peak LH level ≥ 5 IU/L, peak LH/FSH ratio ≥ 0.66 (after 0.1 mg GnRH stimulation test) and a difference of at least 1 year between bone and chronological age.

Results: A statistically significant difference was detected between the groups in serum Omentin-1 and Chemerin levels, and no significant differences were detected between the groups in Visfatin values. The cut-off values for the diagnosis of CPP were calculated as ≤ 48.9 with 81% sensitivity and 54% specificity for Omentin-1, and as ≥ 417 with 85% sensitivity and 60% specificity for Chemerin.

Conclusion: In our study, we found that Omentin-1 level decreased and Chemerin level increased in lean girls with CPP. More studies are needed to elucidate how adipokines play roles in explaining the onset of CPP, and whether they may be used as a reliable marker for the diagnosis of CPP.

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评估中枢性性早熟女孩的血清脂肪因子水平
目的:脂肪组织具有重要的内分泌功能,可分泌多种被称为脂肪因子的激素,如 Visfatin、Omentin-1 和 Chemerin。另一方面,这些激素也会从女孩生殖系统中脂肪组织以外的地方分泌出来。本研究的目的是证明中枢性性早熟(CPP)患者体内脂肪因子的分泌状况及其在诊断性早熟中的作用:研究共纳入 105 名患者(CPP 组 53 人,对照组 52 人)。CPP诊断标准如下:乳房发育、基础LH测量值高于0.3 IU/L、LH峰值≥5 IU/L、LH/FSH峰值比值≥0.66(0.1毫克GnRH刺激试验后)、骨龄与实际年龄相差至少1岁:各组间血清 Omentin-1 和 Chemerin 水平差异有统计学意义,各组间 Visfatin 值无明显差异。根据计算,诊断 CPP 的临界值为:Omentin-1 ≤ 48.9,灵敏度为 81%,特异度为 54%;Chemerin ≥ 417,灵敏度为 85%,特异度为 60%:在我们的研究中,我们发现在患有 CPP 的瘦女孩中,Omentin-1 水平降低,Chemerin 水平升高。还需要更多的研究来阐明脂肪因子在解释 CPP 发病中的作用,以及它们是否可用作诊断 CPP 的可靠标记物。
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来源期刊
Clinical Endocrinology
Clinical Endocrinology 医学-内分泌学与代谢
CiteScore
6.40
自引率
3.10%
发文量
192
审稿时长
1 months
期刊介绍: Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.
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