Research, Development and Pharmacological Activity of Sinomenine and Its Derivatives.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2024-09-18 DOI:10.2174/0109298673323738240830055548
Tieqiang Zong, Jinfeng Sun, Zhengyu Hu, Long Jin, Lantian Cui, Yongkang Xue, Wei Zhou, Gao Li
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Abstract

In this manuscript, the resource distribution, pharmacological activity, pharma-cokinetics of sinomenine and the structure, synthesis, biological activity and mechanism of sinomenine derivatives reported from 2000 to December 2023 were reviewed. The lit-erature was retrieved through Web of Science, PubMed, Science Direct, SciFiner Scholar and other websites. Sinomenine belongs to isoquinoline alkaloids and was extracted from the Chinese herb Sinomenium acutum root. In Asian countries such as China and Japan, it is commonly prescribed as a treatment for rheumatoid arthritis. In addition, sinomenine also has sedative, analgesic, anti-inflammatory, immunosuppressive, neuroprotective, an-ti-drug dependence, anti-tumor and other biological activities. Sinomenine limited its ap-plication prospects because of its large dosage, poor epidermal permeability and short half-life. To overcome these defects, new sinomenine derivatives have been synthesized. Based on the comprehensive analysis of relevant literature at home and abroad, this paper reviews the recent progress in the study of sinomenine's pharmacological effects and structural modifications. Future research on sinomenine will focus on improving its thera-peutic effect, and developing new drug preparations and structural modifications. It is hoped that this review will help to better understand the research progress of sinomenine and provide constructive suggestions for further research of sinomenine.

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西诺明及其衍生物的研究、开发和药理活性。
本手稿综述了2000年至2023年12月期间报道的西诺明的资源分布、药理活性、药代动力学以及西诺明衍生物的结构、合成、生物活性和作用机制。文献通过 Web of Science、PubMed、Science Direct、SciFiner Scholar 等网站进行检索。西诺明属于异喹啉生物碱,从中草药乌头中提取。在中国和日本等亚洲国家,它是治疗类风湿性关节炎的常用处方药。此外,西诺明还具有镇静、镇痛、抗炎、免疫抑制、神经保护、抗药物依赖、抗肿瘤等生物活性。由于西诺明的用量大、表皮渗透性差、半衰期短,限制了其应用前景。为了克服这些缺陷,人们合成了新的西诺明衍生物。本文在综合分析国内外相关文献的基础上,综述了近年来西诺明的药理作用和结构修饰的研究进展。今后有关西诺明的研究将集中在提高其治疗效果、开发新的药物制剂和结构修饰方面。希望本综述有助于更好地了解西诺明的研究进展,并为西诺明的进一步研究提供建设性建议。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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