The Multitarget Action of Vitamins in the Ischemic Stroke.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL Current topics in medicinal chemistry Pub Date : 2024-09-19 DOI:10.2174/0115680266316939240909070627

Luciana Scotti, Pablo Rayff da Silva, Alex France Messias Monteiro, Rodrigo Santos Aquino de Araújo, Vanessa Lima do Nascimento, Kadja Luana Chagas Monteiro, Thiago Mendonça de Aquino, Wadja Feitosa Dos Santos Silva, Edeildo Ferreira da Silva Junior, Marcus T Scotti, Francisco Jaime Bezerra Mendonça Junior

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Abstract

A stroke, also known as a cerebral hemorrhage, occurs when there is an interruption in the blood supply to a part of the brain, resulting in damage to brain cells. This issue is one of the leading causes of death in developed countries, currently killing about 5 million people annually. Individuals who survive ischemic stroke often face serious vision problems, paralysis, dementia, and other sequelae. The numerous efforts to prevent and/or treat stroke sequelae seem insufficient, which is concerning given the increasing global elderly population and the well-known association between aging and stroke risk. In this review, we aim to present and discuss the importance of vitamins in stroke prevention and/or incidence. Vitamins from diet or dietary supplements influence the body at various levels; they are a relevant factor but are reported only in isolated articles. This review reports and updates the multitarget role of vitamins involved in reducing stroke risk.

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维生素在缺血性中风中的多靶点作用

中风又称脑出血，是指大脑部分供血中断，导致脑细胞受损。在发达国家，中风是导致死亡的主要原因之一，目前每年约有 500 万人死于中风。缺血性中风的幸存者通常会面临严重的视力问题、瘫痪、痴呆和其他后遗症。预防和/或治疗脑卒中后遗症的努力似乎还不够，鉴于全球老年人口不断增加，且老龄化与脑卒中风险之间存在众所周知的联系，这种情况令人担忧。在本综述中，我们旨在介绍和讨论维生素在中风预防和/或发病中的重要性。饮食或膳食补充剂中的维生素会在不同层面对人体产生影响；它们是一个相关因素，但只在个别文章中有所报道。本综述报告并更新了维生素在降低中风风险中的多靶点作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.