Genetics of female and male infertility.

IF 1.1 4区 生物学 Medizinische Genetik Pub Date : 2024-09-06 eCollection Date: 2024-09-01 DOI:10.1515/medgen-2024-2040
Corinna Friedrich, Frank Tüttelmann
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Abstract

Infertility is defined as the inability to conceive within one year of unprotected intercourse, and the causes are equally distributed between both sexes. Genetics play a crucial role in couple infertility and respective diagnostic testing should follow available guidelines. Appropriate tiered genetic analyses require comprehensive physical examination of both partners in an infertile couple. A wide range of chromosomal and monogenic variants can be the underlying genetic cause of infertility in both women and men. Accurate clinical phenotyping, together with identification of the genetic origin, helps to recommend the proper treatment and to counsel couples on the success rates and potential risks for offspring.

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女性和男性不孕症的遗传学。
不孕症的定义是在无保护措施的性交后一年内无法受孕,男女双方的不孕原因各占一半。遗传在夫妇不孕症中起着至关重要的作用,相应的诊断测试应遵循现有指南。要进行适当的分层遗传分析,需要对不孕夫妇双方进行全面的身体检查。各种染色体变异和单基因变异都可能是导致男女不孕不育的潜在遗传原因。准确的临床表型分析以及基因来源的鉴定有助于推荐适当的治疗方法,并就成功率和对后代的潜在风险为夫妇提供咨询。
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来源期刊
Medizinische Genetik
Medizinische Genetik GENETICS & HEREDITY-
自引率
9.10%
发文量
48
期刊介绍: medizinischegenetik is a scientific journal that is owned and published by the German Society of Human Genetics e.V. since 1989. The journal was founded by Prof. Jan Murken, München. Self-published until 2006, from 2007-2019 published at Springer Verlag and since 2020 at De Gruyter. medizinischegenetik serves education and training among colleagues, the interdisciplinary exchange of knowledge in all areas of human genetics in clinics, practice, research and teaching. Each issue of the quarterly journal deals with a focus that provides a comprehensive overview of current developments in specific clinical pictures, technical developments and therapeutic approaches. All reviews are written in English language. The journal thus creates a platform for the international exchange of knowledge and increased awareness of German research activities in the scientific community. In addition, medizinischegenetik contains information on activities in its own subject in the German-language section. This includes conference reports, association announcements, personnel matters, statements and guidelines. With health policy questions, historical retrospectives and comments on current developments, the profession takes a stand on human genetic issues in Germany, Austria and Switzerland.
期刊最新文献
"Wir gründeten die Zeitschrift medizinischegenetik, weil die Humangenetiker ein Forum für ihr Fach brauchten": Der Initiator Prof. Dr. med. Jan Murken über die Herausforderungen und Notwendigkeiten, in den ausgehenden 80er Jahren eine deutschsprachige Zeitschrift zu gründen - ein Interview anlässlich seines 90. Geburtstags. 10 Years of International Albinism Awareness: United Nations celebrate an anniversary and a decade of collective progress, but challenges remain. 37. Tumorgenetische Arbeitstagung: 8.–10. Mai 2025, Leipzig. Genetics of female and male infertility. GfH-Promotionspreise 2024.
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