Effect of Combined Exercise and Nutrition Interventions During Inpatient Chemotherapy in Acute Leukemia and Malignant Lymphoma Patients: A Randomized Controlled Trial.

IF 2 4区医学 Q3 NUTRITION & DIETETICS Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-19 DOI:10.1080/01635581.2024.2406043

Ryuichi Kasahara, Shinichiro Morishita, Takaaki Fujita, Ryohei Jinbo, Junko Kubota, Aya Takano, Shoko Takahashi, Sayaka Kisara, Kazumi Jinbo, Yuichi Yamamoto, Masae Kakuta, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Shigehira Saji

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Abstract

The aim of the present study was to determine the effectiveness of combined exercise and nutrition interventions on physical function and quality of life (QOL) in patients with acute leukemia or malignant lymphoma (ML) during inpatient chemotherapy. The study was a randomized controlled trial where patients with acute leukemia or ML who were receiving inpatient chemotherapy and exercise therapy were divided into an intervention group (IG) and a control group (CG). Both groups underwent resistance training and aerobic exercise. The patients in the IG were instructed to take nutritional supplements twice a day. Assessment items were muscle strength (handgrip strength and knee extension strength), 6-min walking test, skeletal muscle mass, QOL, nutritional status, and fatigue. Two-way analysis of variance showed a significant interaction for bilateral handgrip strength and knee extension strength. No significant interactions were found for the other items. The results of the present study showed improved muscle strength in the IG compared to the CG, indicating the effectiveness of combined exercise and nutrition interventions during inpatient chemotherapy in patients with acute leukemia or ML.

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急性白血病和恶性淋巴瘤患者住院化疗期间运动和营养联合干预的效果：随机对照试验

本研究旨在确定运动与营养相结合的干预措施对住院化疗期间急性白血病或恶性淋巴瘤（ML）患者的身体功能和生活质量（QOL）的影响。该研究是一项随机对照试验，将接受住院化疗和运动疗法的急性白血病或恶性淋巴瘤患者分为干预组（IG）和对照组（CG）。两组患者均接受阻力训练和有氧运动。干预组患者被指导每天服用两次营养补充剂。评估项目包括肌力（手握力和膝关节伸展力）、6 分钟步行测试、骨骼肌质量、QOL、营养状况和疲劳。双向方差分析显示，双侧握力和伸膝力量存在显著的交互作用。其他项目没有发现明显的交互作用。本研究结果表明，与 CG 相比，IG 的肌肉力量有所改善，这表明在急性白血病或 ML 患者住院化疗期间进行运动和营养联合干预是有效的。

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.