Ziyuan Dai, Qiang Lu, Mingzhong Sun, Hongmei Chen, Rong Zhu, Huiqing Wang
{"title":"Identification of a Novel Parvovirus in the Arctic Wolf (<i>Canis lupus arctos</i>).","authors":"Ziyuan Dai, Qiang Lu, Mingzhong Sun, Hongmei Chen, Rong Zhu, Huiqing Wang","doi":"10.33073/pjm-2024-035","DOIUrl":null,"url":null,"abstract":"<p><p>A novel virus, temporarily named \"Arctic wolf parvovirus\" (AWPV), was discovered in a pharyngeal metagenomic library derived from an Arctic wolf (<i>Canis lupus arctos</i>) in China. The genome sequence was assigned GenBase accession number C_AA071902.1. AWPV has a genome comprised of 4,920 base pairs with a nucleotide composition of 36.4% A, 23.4% T, 18.2% G, and 22.0% C, with a GC content of 40.2%. Its structure resembles parvoviruses, containing two open reading frames: the nonstructural (NS) region encoding replication enzymes and the structural (VP) region encoding capsid protein. Pairwise sequence comparison and phylogenetic analysis suggest AWPV may represent a novel species within the genus <i>Protoparvovirus</i>. This discovery enhances our understanding of mammalian virus ecology and potential future infectious diseases.</p>","PeriodicalId":94173,"journal":{"name":"Polish journal of microbiology","volume":"73 3","pages":"395-401"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11395419/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polish journal of microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33073/pjm-2024-035","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
A novel virus, temporarily named "Arctic wolf parvovirus" (AWPV), was discovered in a pharyngeal metagenomic library derived from an Arctic wolf (Canis lupus arctos) in China. The genome sequence was assigned GenBase accession number C_AA071902.1. AWPV has a genome comprised of 4,920 base pairs with a nucleotide composition of 36.4% A, 23.4% T, 18.2% G, and 22.0% C, with a GC content of 40.2%. Its structure resembles parvoviruses, containing two open reading frames: the nonstructural (NS) region encoding replication enzymes and the structural (VP) region encoding capsid protein. Pairwise sequence comparison and phylogenetic analysis suggest AWPV may represent a novel species within the genus Protoparvovirus. This discovery enhances our understanding of mammalian virus ecology and potential future infectious diseases.
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