Which dose of calcium dobesilate is more effective and safe in chronic venous insufficiency? Multicenter retrospective clinical trial.

Oguz Arslanturk, Barıs Uymaz, Fatih Gumus
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Abstract

Objectives: This study aimed to evaluate the effectiveness and safety of different dosages of calcium dobesilate in the management of Chronic Venous Insufficiency (CVI) among patients in CEAP classes C3-C4.

Methods: A comprehensive multicenter retrospective analysis was conducted, including patients aged 18-70 with CEAP class C3-C4 CVI. Participants were divided into two groups: one receiving 500 mg of calcium dobesilate twice daily and the other 1000 mg twice daily. Patient progress was monitored using the Global Index Score, CIVIC-20 Score, and precise measurements of ankle and calf circumferences over a 12-month period.

Results: The higher dosage group (1000 mg twice daily) showed significant improvements in both symptom relief and edema reduction. Ankle circumference reduced notably at 6 months, while calf circumference and overall quality of life, measured by the Global Index Score, showed significant improvement by 12 months compared to the lower dosage group.

Conclusions: Higher doses of calcium dobesilate markedly enhance the management of CVI symptoms and reduce edema more effectively than lower doses, particularly in patients with advanced CVI. These findings support the use of higher dosages for optimal treatment, though further research is needed to fully evaluate long-term safety.

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哪种剂量的多贝西酸钙对慢性静脉功能不全更有效、更安全?多中心回顾性临床试验。
研究目的本研究旨在评估不同剂量的多贝西酸钙在治疗 CEAP C3-C4 级慢性静脉功能不全(CVI)患者中的有效性和安全性:方法: 我们进行了一项全面的多中心回顾性分析,研究对象包括 18-70 岁的 CEAP C3-C4 级慢性静脉功能不全患者。参与者被分为两组:一组接受 500 毫克多贝酯钙,每天两次;另一组接受 1000 毫克多贝酯钙,每天两次。在为期 12 个月的时间里,使用全球指数评分、CIVIC-20 评分以及脚踝和小腿周长的精确测量来监测患者的病情进展:结果:高剂量组(1000 毫克,每天两次)在缓解症状和减轻水肿方面均有显著改善。与低剂量组相比,踝围在 6 个月时明显缩小,而小腿围和总体生活质量(通过全球指数评分)在 12 个月时有明显改善:结论:与低剂量相比,高剂量多贝司酸钙能明显加强对CVI症状的控制,更有效地减轻水肿,尤其是对晚期CVI患者。这些研究结果支持使用较大剂量进行最佳治疗,但还需要进一步的研究来全面评估长期安全性。
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