RETRACTION: The Novel Role of Circular RNA ST3GAL6 on Blocking Gastric Cancer Malignant Behaviours Through Autophagy Regulated by the FOXP2/MET/Mtor Axis

IF 7.9 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Translational Medicine Pub Date : 2024-09-24 DOI:10.1002/ctm2.70025

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引用次数: 0

Abstract

RETRACTION: P. Xu, X. Zhang, J. Cao, J. Yang, Z. Chen, W. Wang, S. Wang, L. Zhang, L. Xie, L. Fang, Y. Xia, Z. Xuan, J. Lv, H. Xu, and Z. Xu, “The Novel Role of Circular RNA ST3GAL6 on Blocking Gastric Cancer Malignant Behaviours Through Autophagy Regulated by the FOXP2/MET/Mtor Axis,” Clinical and Translational Medicine 12, no.1 (2022): e707, https://doi.org/10.1002/ctm2.707.

The above article, published online on 21 January 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Xiangdong Wang; the Shanghai Institute of Clinical Bioinformatics; and John Wiley & Sons Australia, Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate duplications of image panels within the article (Figures 6H and 7J) and between this article (Figures 2D, 7B, 7K, 8E and 8J) and another article previously published elsewhere by an overlapping group of authors in a different scientific context. The authors were unable to provide a satisfactory explanation and the raw data they supplied could not explain the identified issues. In addition, the cell line SGC-7901 used in this study has been reported as contaminated with HeLa cells, making it a problematic model for gastric cancer [1,2]. Given the extent of the identified issues, the editors have lost confidence in the data presented and the article's conclusions can no longer be considered reliable.

References

[1] F. Ye, C. Chen, J. Qin, J. Liu, and C. Zheng, “Genetic Profiling Reveals an Alarming Rate of Cross-Contamination Among Human Cell Lines Used in China,” The FASEB Journal 29, no. 10 (2015):4268–4272, https://doi.org/10.1096/fj.14-266718.

[2] X. Bian, Z. Yang, H. Feng, H. Sun, and Y. Liu, “A Combination of Species Identification and STR Profiling Identifies Cross-contaminated Cells from 482 Human Tumor Cell Lines,” Scientific Reports 7, no. 1 (2017):9774, https://doi.org/10.1038/s41598-017-09660-w.

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回归：环状 RNA ST3GAL6 在 FOXP2/MET/Mtor 轴调控下通过自噬阻断胃癌恶性行为的新作用

撤回：P. Xu, X. Zhang, J. Cao, J. Yang, Z. Chen, W. Wang, S. Wang, L. Zhang, L. Xie, L. Fang, Y. Xia, Z. Xuan, J. Lv, H. Xu, and Z. Xu, "Novel Role of Circular RNA ST3GAL6 on Blocking Gastric Cancer Malignhaviours Through Autophagy Regulated by FOXP2/ MGM, the Journal of Journal of Clinical Research, 2009.Xu, "The Novel Role of Circular RNA ST3GAL6 on Blocking Gastric Cancer Malignant Behaviours Through Autophagy Regulated by the FOXP2/MET/Mtor Axis," Clinical and Translational Medicine 12, no.(2022): e707, https://doi.org/10.1002/ctm2.707。上述文章于 2022 年 1 月 21 日在线发表于 Wiley Online Library (wileyonlinelibrary.com)，经杂志主编王向东、上海临床生物信息研究所和 John Wiley & Sons Australia, Ltd.（澳大利亚约翰威利父子公司）协商，现予以撤稿。在对第三方提出的疑虑进行调查后，我们同意撤稿。调查显示，文章（图 6H 和 7J）中的图像面板与本文（图 2D、7B、7K、8E 和 8J）中的图像面板存在不恰当的重复，而这篇文章与之前由一组相同作者在不同科学背景下发表的另一篇文章之间也存在不恰当的重复。作者无法提供令人满意的解释，他们提供的原始数据也无法解释发现的问题。此外，这项研究中使用的细胞系 SGC-7901 已被报道受到 HeLa 细胞的污染，使其成为一个有问题的胃癌模型[1,2]。鉴于所发现问题的严重性，编辑对所提供的数据失去了信心，文章的结论也不再可靠。参考文献 [1] F. Ye, C. Chen, J. Qin, J. Liu, and C. Zheng, "Genetic Profiling Reveals an Alarming Rate of Cross-Contamination Among Human Cell Lines Used in China," The FASEB Journal 29, no. 10 (2015):4268-4272, https://doi.org/10.1096/fj.14-266718.[2] X. Bian, Z. Yang, H. Feng, H. Sun, and Y. Liu, "A Combination of Species Identification and STR Profiling Identifies Cross-contaminated Cells from 482 Human Tumor Cell Lines," Scientific Reports 7, no. 1 (2017):9774, https://doi.org/10.1038/s41598-017-09660-w.

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来源期刊

Clinical and Translational Medicine Multiple-

CiteScore

15.90

自引率

1.90%

发文量

450

审稿时长

4 weeks

期刊介绍： Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.