Delineating the NOX-Mediated Promising Therapeutic Strategies for the Management of Various Cardiovascular Disorders: A Comprehensive Review.

IF 2.8 3区医学 Q2 PERIPHERAL VASCULAR DISEASE Current vascular pharmacology Pub Date : 2024-09-20 DOI:10.2174/0115701611308870240910115023

Rohit Kumar Upadhyay, Kuldeep Kumar, Vishal Kumar Vishwakarma, Nirmal Singh, Rajeev Narang, Neeraj Parakh, Mayank Yadav, Sangeeta Yadav, Sachin Kumar, Ahsas Goyal, Harlokesh Narayan Yadav

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Abstract

Cardiovascular disorders (CVDs) are reported to occur with very high rates of incidence and exhibit high morbidity and mortality rates across the globe. Therefore, research is focused on searching for novel therapeutic targets involving multiple pathophysiological mechanisms. Oxidative stress plays a critical role in the development and progression of various CVDs, such as hypertension, pulmonary hypertension, heart failure, arrhythmia, atherosclerosis, ischemia-reperfusion injury, and myocardial infarction. Among multiple pathways generating reactive oxygen species (ROS), NADPH defines all abbreviations oxidases of the NOX family as the major source of ROS generation and plays an intricate role in the development and progression of CVDs. Therefore, exploring the role of different NADPH oxidase isoforms in various cardiovascular pathologies has attracted attention to current cardiovascular research. Focusing on NADPH oxidases to reduce oxidative stress in managing diverse CVDs may offer unique therapeutic approaches to prevent and treat various heart conditions. The current review article highlights the role of different NADPH oxidase isoforms in the pathophysiology of various CVDs. Moreover, the focus is also to emphasize different experimental studies that utilized various NADPH oxidase isoform modulators to manage other disorders. The present review article considers new avenues for researchers/scientists working in the field of cardiovascular pharmacology utilizing NADPH oxidase isoform modulators.

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划定 NOX 介导的治疗各种心血管疾病的可行策略：全面回顾。

据报道，心血管疾病（CVD）的发病率非常高，在全球范围内的发病率和死亡率也很高。因此，研究重点是寻找涉及多种病理生理机制的新型治疗靶点。氧化应激在高血压、肺动脉高压、心力衰竭、心律失常、动脉粥样硬化、缺血再灌注损伤和心肌梗死等各种心血管疾病的发生和发展过程中起着至关重要的作用。在产生活性氧（ROS）的多种途径中，NADPH 定义为 NOX 家族的所有缩写氧化酶是产生 ROS 的主要来源，在心血管疾病的发生和发展过程中发挥着错综复杂的作用。因此，探索不同 NADPH 氧化酶同工酶在各种心血管病变中的作用已引起当前心血管研究的关注。关注 NADPH 氧化酶以减少氧化应激，从而控制各种心血管疾病，可能会为预防和治疗各种心脏疾病提供独特的治疗方法。本综述文章重点介绍了不同的 NADPH 氧化酶同工酶在各种心血管疾病的病理生理学中的作用。此外，文章还着重介绍了利用各种 NADPH 氧化酶同工酶调节剂治疗其他疾病的不同实验研究。本综述文章为利用 NADPH 氧化酶同工酶调节剂在心血管药理学领域工作的研究人员/科学家提供了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current vascular pharmacology 医学-外周血管病

CiteScore

9.20

自引率

4.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Vascular Pharmacology publishes clinical and research-based reviews/mini-reviews, original research articles, letters, debates, drug clinical trial studies and guest edited issues to update all those concerned with the treatment of vascular disease, bridging the gap between clinical practice and ongoing research. Vascular disease is the commonest cause of death in Westernized countries and its incidence is on the increase in developing countries. It follows that considerable research is directed at establishing effective treatment for acute vascular events. Long-term treatment has also received considerable attention (e.g. for symptomatic relief). Furthermore, effective prevention, whether primary or secondary, is backed by the findings of several landmark trials. Vascular disease is a complex field with primary care physicians and nurse practitioners as well as several specialties involved. The latter include cardiology, vascular and cardio thoracic surgery, general medicine, radiology, clinical pharmacology and neurology (stroke units).