Association between rs3761548 polymorphism of FOXP3 and the risk of gastric cancer: a case-control study.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biology Research Communications Pub Date : 2024-01-01 DOI:10.22099/mbrc.2024.49125.1989

Shamimeh Validi, Iraj Saadat

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Abstract

Gastric cancer is one of the most prevalent malignancies in the world. Various factors play a role in the development of this disease as risk factors. One of these genes is the FOXP3, which is located on the short arm of the X chromosome (Xp11.23). The rs3761548 polymorphism in the promoter region of this gene increases cell proliferation. In the current study, the association between this genetic polymorphism and the risk of gastric cancer was investigated. This study included 147 patients (55 women, 92 men) with gastric cancer and 147 healthy individuals (53 women, 94 men). The PCR-RFLP method is used for genotyping. Statistical analysis showed that there was no significant association between this polymorphism and the risk of gastric cancer. However, the analysis of genotype, family history and smoking risk factors simultane-oussly revealed a significant relationship between simultaneous occurrence of two (OR=3.79, 95% CI=1.77-8.09, p=0.001) and three risk factors (OR=6.44, 95% CI=1.76-23.5, p=0.017) and the risk of gastric cancer.

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FOXP3的rs3761548多态性与胃癌风险的关系：一项病例对照研究。

胃癌是世界上最常见的恶性肿瘤之一。在这种疾病的发病过程中，有多种风险因素在起作用。其中一个基因是位于 X 染色体短臂（Xp11.23）上的 FOXP3。该基因启动子区域的 rs3761548 多态性会增加细胞增殖。本研究调查了该基因多态性与胃癌风险之间的关系。这项研究包括 147 名胃癌患者（55 名女性，92 名男性）和 147 名健康人（53 名女性，94 名男性）。采用 PCR-RFLP 方法进行基因分型。统计分析表明，该多态性与胃癌风险无明显关联。然而，同时对基因型、家族史和吸烟风险因素进行分析后发现，同时出现两种风险因素（OR=3.79，95% CI=1.77-8.09，P=0.001）和三种风险因素（OR=6.44，95% CI=1.76-23.5，P=0.017）与胃癌风险之间存在显著关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Molecular Biology Research Communications BIOCHEMISTRY & MOLECULAR BIOLOGY-

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3.00

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0.00%

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期刊介绍： “Molecular Biology Research Communications” (MBRC) is an international journal of Molecular Biology. It is published quarterly by Shiraz University (Iran). The MBRC is a fully peer-reviewed journal. The journal welcomes submission of Original articles, Short communications, Invited review articles, and Letters to the Editor which meets the general criteria of significance and scientific excellence in all fields of “Molecular Biology”.