Exosomal non-coding RNAs (ncRNAs) as potential biomarkers in tumor early diagnosis

IF 9.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-09-21 DOI:10.1016/j.bbcan.2024.189188
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Abstract

Exosomes, extracellular vesicles carrying a cargo rich in various non-coding RNAs (ncRNAs), have emerged as crucial mediators of intercellular communication. Their stability, abundance, and specificity make exosomal ncRNAs promising candidates for biomarker discovery. The discovery of exosomal ncRNAs has unveiled a novel avenue for the exploration of biomarkers in tumor early diagnosis. This review consolidates current knowledge on the role of exosomal ncRNAs as potential biomarkers in the early detection of various tumors. We provide an overview of recent studies demonstrating the diagnostic potential of exosomal ncRNAs across multiple cancer types, highlighting their sensitivity, specificity, and feasibility for early detection. This review underscores the potential of exosomal ncRNAs as non-invasive biomarkers for early tumor diagnosis, paving the way for improved clinical outcomes through timely intervention and personalized management strategies.
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外泌体非编码 RNA(ncRNA)作为肿瘤早期诊断的潜在生物标记物。
外泌体是一种细胞外囊泡,携带着富含各种非编码 RNA(ncRNA)的货物,已成为细胞间通信的重要媒介。外泌体 ncRNA 的稳定性、丰富性和特异性使其成为发现生物标记物的理想候选物。外泌体 ncRNA 的发现为探索肿瘤早期诊断的生物标志物开辟了一条新途径。本综述整合了目前关于外泌体 ncRNA 作为潜在生物标记物在各种肿瘤早期检测中的作用的知识。我们概述了证明外泌体 ncRNA 在多种癌症类型中的诊断潜力的最新研究,强调了它们在早期检测中的敏感性、特异性和可行性。这篇综述强调了外泌体 ncRNA 作为非侵入性生物标记物用于早期肿瘤诊断的潜力,为通过及时干预和个性化管理策略改善临床结果铺平了道路。
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来源期刊
Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学
CiteScore
17.20
自引率
0.00%
发文量
138
审稿时长
33 days
期刊介绍: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.
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