Role of organometallic complexes in targeted therapies of different diseases: Infectious diseases, cancer and neurodegenerative Diseases

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Journal of Organometallic Chemistry Pub Date : 2024-09-19 DOI:10.1016/j.jorganchem.2024.123389

Nitin V , Tanmay Anand , Chandra Kant Singh , Kushneet Kaur Sodhi

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Abstract

Organometallic complexes have garnered attention in the design of metal chemotherapeutics in recent years because of their exceptional stability and distinct characteristics when compared to conventional coordination complexes. Organometallic complexes are perfect for regulating drug release and improving cellular uptake because of their redox potentials, ligand exchange kinetics, and distinctive reactivity profiles. Many studies have been conducted to investigate the antiviral, anticancer, antibacterial, antifungal, and antiparasitic activities of metal complexes. Numerous complexes possessing intriguing biological characteristics have been created. Significantly, several disorders are treated with specific metal complexes. An overview of the organometallics used in medicine, particularly those with antimicrobial and anti-cancer capabilities, complexes used to treat neurological illnesses, and difficulties encountered in this specific field, have been presented in this work. This review's main goal is to give readers an overview of the noteworthy advancements of organometallics made in each of these many medical specialties.

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有机金属复合物在不同疾病的靶向治疗中的作用：传染病、癌症和神经退行性疾病

与传统配位络合物相比，有机金属络合物具有优异的稳定性和独特的特性，因此近年来在金属化学疗法的设计中备受关注。有机金属配合物具有氧化还原电位、配体交换动力学和独特的反应性，是调节药物释放和改善细胞吸收的理想选择。已有许多研究对金属配合物的抗病毒、抗癌、抗菌、抗真菌和抗寄生虫活性进行了调查。许多具有令人感兴趣的生物特性的络合物应运而生。重要的是，一些疾病可通过特定的金属复合物得到治疗。本研究综述了医学中使用的有机金属，尤其是那些具有抗菌和抗癌能力的有机金属、用于治疗神经系统疾病的复合物，以及在这一特定领域遇到的困难。这篇综述的主要目的是向读者概述有机金属在众多医学专业中取得的显著进步。

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.