Cu(I)-Catalyzed Highly Regioselective C–H Amidation of Quinoline N-Oxides with Dioxazolones

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-09-30 DOI:10.1021/acs.orglett.4c03118

Zhiqiang Ren, Tianhui Feng, Tianli Gao, Bo Han, Ruili Guo, Haojie Ma, Ji-Jiang Wang, Yuqi Zhang

引用次数: 0

Abstract

A Cu(I)-catalyzed highly regioselective synthesis of 2-acetamidequinoline N-oxides using dioxazolones with quinoline N-oxides has been reported. The reaction possesses mild reaction conditions and excellent functional group compatibility. Furthermore, the addition of hydrochloric acid promotes the decomposition of copper complexes, which is beneficial for postprocessing.

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Cu(I)-Catalyzed Highly Regioselective C-H Amidation of Quinoline N-Oxides with Dioxazolones（Cu(I)催化喹啉 N-氧化物与二噁唑酮的高区域选择性 C-H 酰胺化反应

据报道，该研究利用二恶唑酮与喹啉 N-氧化物，在 Cu(I)- 催化下高区域选择性合成了 2-乙酰胺喹啉 N-氧化物。该反应具有温和的反应条件和良好的官能团相容性。此外，加入盐酸可促进铜络合物的分解，有利于后处理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.