Association of length of hospital stay, total body surface area burned, and Carbapenem-Resistant Klebsiella pneumoniae infection in burn patients: A retrospective study

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE Burns Pub Date : 2024-11-01 Epub Date: 2024-09-20 DOI:10.1016/j.burns.2024.09.006

Qiang Li , Xu Zhang , Yanhua Ding , Ya Sun , Jiangxia Zhang

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Abstract

Background

The specific relationships between total body surface area burned (TBSA), length of stay (LOS), and carbapenem-resistant Klebsiella pneumoniae (CRKP) infection remain unclear. This study aimed to explore the relationship between TBSA and CRKP infection and to examine whether LOS mediates the association between TBSA and the risk of CRKP infection.

Methods

We retrospectively collected the clinical data of adult burn patients admitted to Nanyang Nanshi Hospital between 2021 and 2023. We used multivariate logistic regression analysis to study the risk factors for CRKP infection; restricted cubic spline analysis to investigate the associations between TBSA, LOS, and CRKP infection; and mediation analysis to examine whether LOS mediated the association between TBSA and CRKP infection.

Results

A total of 178 subjects were included in the study; 104 (58.4 %) were male, and the median age was 47 (33−59) years. Thirty-one (17.4 %) subjects developed CRKP infection. Both TBSA and LOS showed a linear positive correlation with the risk of CRKP infection. The LOS mediated the association between TBSA and incident CRKP infection, with a proportion of 17.6 %.

Conclusion

The risk of CRKP infection linearly increased as TBSA or LOS increased, and LOS mediated approximately 20 % of the total association between TBSA and CRKP infection.

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烧伤患者的住院时间、烧伤总体表面积与耐碳青霉烯类肺炎克雷伯菌感染的关系：回顾性研究。

背景：烧伤总体表面积（TBSA）、住院时间（LOS）和耐碳青霉烯类肺炎克雷伯菌（CRKP）感染之间的具体关系仍不清楚。本研究旨在探讨烧伤体表面积（TBSA）与 CRKP 感染之间的关系，并研究住院时间是否介导了烧伤体表面积（TBSA）与 CRKP 感染风险之间的关系：我们回顾性地收集了2021年至2023年间南阳南石医院收治的成年烧伤患者的临床数据。我们使用多变量逻辑回归分析研究CRKP感染的风险因素；使用限制性立方样条分析研究TBSA、LOS和CRKP感染之间的关联；使用中介分析研究LOS是否介导了TBSA和CRKP感染之间的关联：研究共纳入了 178 名受试者，其中 104 人（58.4%）为男性，年龄中位数为 47（33-59）岁。31名受试者（17.4%）感染了CRKP。TBSA和LOS均与CRKP感染风险呈线性正相关。LOS介导了TBSA与CRKP感染之间的关系，比例为17.6%：结论：CRKP感染风险随着TBSA或LOS的增加而线性增加，LOS介导了TBSA与CRKP感染之间总关联的约20%。

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来源期刊

Burns 医学-皮肤病学

CiteScore

4.50

自引率

18.50%

发文量

304

审稿时长

72 days

期刊介绍： Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice. Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.