Anti-inflammatory Prowess of endothelial progenitor cells in the realm of biology and medicine.

IF 6.4 1区医学 Q1 CELL & TISSUE ENGINEERING npj Regenerative Medicine Pub Date : 2024-09-30 DOI:10.1038/s41536-024-00365-z

Mehdi Hassanpour, Amankeldi A Salybkov, Shuzo Kobayashi, Takayuki Asahara

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Abstract

Endothelial inflammation plays a crucial role in vascular-related diseases, a leading cause of global mortality. Among various cellular players, endothelial progenitor cells (EPCs) emerge as non-differentiated endothelial cells circulating in the bloodstream. Recent evidence highlights the transformative role of EPCs in shifting from an inflammatory/immunosuppressive crisis to an anti-inflammatory/immunomodulatory response. Despite the importance of these functions, the regulatory mechanisms governing EPC activities and their physiological significance in vascular regenerative medicine remain elusive. Surprisingly, the current literature lacks a comprehensive review of EPCs' effects on inflammatory processes. This narrative review aims to fill this gap by exploring the cutting-edge role of EPCs against inflammation, from molecular intricacies to broader medical perspectives. By examining how EPCs modulate inflammatory responses, we aim to unravel their anti-inflammatory significance in vascular regenerative medicine, deepening insights into EPCs' molecular mechanisms and guiding future therapeutic strategies targeting vascular-related diseases.

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内皮祖细胞在生物学和医学领域的抗炎能力。

内皮炎症在血管相关疾病中起着至关重要的作用，是导致全球死亡的主要原因。在各种细胞角色中，内皮祖细胞（EPCs）是血液中循环的非分化内皮细胞。最近的证据突显了 EPCs 在从炎症/免疫抑制危机转变为抗炎/免疫调节反应中的转化作用。尽管这些功能非常重要，但 EPC 活动的调控机制及其在血管再生医学中的生理意义仍然难以捉摸。令人惊讶的是，目前的文献缺乏关于 EPC 对炎症过程影响的全面综述。这篇叙述性综述旨在填补这一空白，从分子的复杂性到更广泛的医学视角，探讨 EPCs 在抗炎方面的前沿作用。通过研究 EPCs 如何调节炎症反应，我们旨在揭示其在血管再生医学中的抗炎意义，加深对 EPCs 分子机制的了解，并指导未来针对血管相关疾病的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.