"High-risk" tumors of the lip treated with external beam radiotherapy and high-dose-rate brachytherapy: Long-term outcome.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-09-26 DOI:10.1002/hed.27936

Claes Mercke, Signe Friesland, Anders Berglund, Gun Wickart Johansson, Gregori Margolin, Michael Gubanski, Einar Björgvinsson, Josef Nilsson

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Abstract

Background: Radiotherapy is a well-established treatment for lip cancer, with external radiotherapy (EBRT) or brachytherapy (BT).

Methods: This study evaluated outcome, tumor control, and aesthetics, for 101 patients with carcinoma of the lip, not suitable for surgery, treated with combined EBRT and BT.

Results: Squamous cell carcinoma was seen in 78 patients, basal cell carcinoma in 15, and other histologies in 8 patients. Tumors were advanced: 73% in category T2-T4. Local control at 3 and 5 years was 89%. Local failure appeared in 4/56 patients (7%) with primary RT compared to 7/45 (16%) in those with prior surgery, regional recurrence in 5 patients. Toxicity was mild. Cosmetic outcome, 87 patients evaluated, was bad for 9/40 patients with upfront surgery compared to 1/47 for primary RT patients (p = 0.003). Seven patients died from lip cancer (7%), three with originally N+ disease (43%).

Conclusions: Combined EBRT and BT could be considered for lip tumors not candidates for surgery.

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采用体外放射治疗和高剂量率近距离放射治疗的唇部 "高危 "肿瘤：长期疗效。

背景：放疗是治疗唇癌的一种行之有效的方法：放疗是治疗唇癌的一种行之有效的方法，可采用体外放射治疗（EBRT）或近距离放射治疗（BT）：本研究评估了 101 名不适合手术的唇癌患者接受 EBRT 和 BT 联合治疗后的疗效、肿瘤控制和美学效果：78例患者为鳞状细胞癌，15例患者为基底细胞癌，8例患者为其他组织类型。肿瘤为晚期：73%为T2-T4类。3年和5年的局部控制率为89%。4/56（7%）名患者接受了初治 RT，7/45（16%）名患者接受了手术，5名患者出现了局部复发。毒性较轻。在接受评估的87名患者中，9/40的患者接受了前期手术，而1/47的患者接受了初治RT（P = 0.003）。7名患者死于唇癌（7%），其中3名患者原本患有N+疾病（43%）：结论：对于不适合手术的唇部肿瘤，可以考虑联合使用EBRT和BT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.