Revolutionising Neurological Therapeutics: Investigating Drug Repurposing Strategies.

Meenakshi Attri, Asha Raghav, Jyoti Sinha
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Abstract

Repurposing drugs (DR) has become a viable approach to hasten the search for cures for neurodegenerative diseases (NDs). This review examines different off-target and on-target drug discovery techniques and how they might be used to find possible treatments for non-diagnostic depressions. Off-target strategies look at the known or unknown side effects of currently approved drugs for repositioning, whereas on-target strategies connect disease pathways to targets that can be treated with drugs. The review highlights the potential of experimental and computational methodologies, such as machine learning, proteomic techniques, network and genomics-based approaches, and in silico screening, in uncovering new drug-disease correlations. It also looks at difficulties and failed attempts at drug repurposing for NDs, highlighting the necessity of exact and standardised procedures to increase success rates. This review's objectives are to address the purpose of drug repurposing in human disorders, particularly neurological diseases, and to provide an overview of repurposing candidates that are presently undergoing clinical trials for neurological conditions, along with any possible causes and early findings. We then include a list of drug repurposing strategies, restrictions, and difficulties for upcoming research.

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神经病学疗法的革命:研究药物再利用战略。
药物再利用(DR)已成为加速寻找神经退行性疾病(NDs)治疗方法的一种可行方法。本综述探讨了不同的非靶向和靶向药物发现技术,以及如何利用这些技术找到治疗非诊断性抑郁症的可能方法。非靶点策略关注目前已批准药物的已知或未知副作用,以便重新定位,而靶点策略则将疾病通路与可以用药物治疗的靶点联系起来。综述强调了实验和计算方法在发现新的药物-疾病相关性方面的潜力,如机器学习、蛋白质组技术、基于网络和基因组学的方法以及硅学筛选。本综述还探讨了针对 NDs 的药物再利用所遇到的困难和失败的尝试,强调了精确和标准化程序对提高成功率的必要性。本综述的目的是探讨在人类疾病(尤其是神经系统疾病)中进行药物再利用的目的,并概述目前正在进行神经系统疾病临床试验的再利用候选药物,以及任何可能的原因和早期发现。然后,我们列出了药物再利用的策略、限制和即将开展的研究的困难。
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