An overview of the progress made in research into the Mpox virus.

IF 10.9 1区 医学 Q1 CHEMISTRY, MEDICINAL Medicinal Research Reviews Pub Date : 2024-09-24 DOI:10.1002/med.22085
Yansheng Li, Lianrong Wang, Shi Chen
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Abstract

Mpox is a zoonotic illness caused by the Mpox virus (MPXV), a member of the Orthopoxvirus family. Although a few cases have been reported outside Africa, it was originally regarded as an endemic disease limited to African countries. However, the Mpox outbreak of 2022 was remarkable in that the infection spread to more than 123 countries worldwide, causing thousands of infections and deaths. The ongoing Mpox outbreak has been declared as a public health emergency of international concern by the World Health Organization. For a better management and control of the epidemic, this review summarizes the research advances and important scientific findings on MPXV by reviewing the current literature on epidemiology, clinical characteristics, diagnostic methods, prevention and treatment measures, and animal models of MPXV. This review provides useful information to raise awareness about the transmission, symptoms, and protective measures of MPXV, serving as a theoretical guide for relevant institutions to control MPXV.

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Mpox 病毒研究进展概述。
痘疹是由痘疹病毒(MPXV)引起的人畜共患疾病,MPXV 是正痘病毒家族的成员。虽然非洲以外也有少数病例报告,但它最初被认为是一种仅限于非洲国家的地方病。然而,2022 年爆发的麻风腮疫情却令人瞩目,因为感染扩散到全球超过 123 个国家,造成数千人感染和死亡。世界卫生组织已宣布当前的麻风腮疫情为国际关注的突发公共卫生事件。为了更好地管理和控制疫情,本综述通过回顾有关 MPXV 的流行病学、临床特征、诊断方法、预防和治疗措施以及动物模型的现有文献,总结了有关 MPXV 的研究进展和重要科学发现。本综述为提高人们对 MPXV 的传播途径、症状和防护措施的认识提供了有用信息,为相关机构控制 MPXV 提供了理论指导。
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来源期刊
CiteScore
29.30
自引率
0.00%
发文量
52
审稿时长
2 months
期刊介绍: Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.
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Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities. Issue Information Front Cover Image, Volume 44, Issue 6 Inside Front Cover Image, Volume 44, Issue 6 An overview of the progress made in research into the Mpox virus.
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