Regulatory Involvement of Kisspeptin in Energy Balance and Reproduction.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Biochemistry and Biophysics Pub Date : 2024-09-26 DOI:10.1007/s12013-024-01537-w

P A Oyedokun, M A Akangbe, T M Akhigbe, R E Akhigbe

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Abstract

The hypothalamic-pituitary-gonadal axis, which regulates steroidogenesis and germ cell formation, closely regulates the reproduction process. Nonetheless, other chemical mediators, such as kisspeptin, influence this axis. Kisspeptin is a hypothalamic neuropeptide that modulates the function of this axis and also plays a central role in energy balance. The present study reviews the impact and associated mechanisms of kisspeptin on male and female reproduction based on available evidence in the literature. Kisspeptin and its neurons exert anorexigenic activity, thus maintaining adequate energy balance for optimal reproductive function. Also, they stimulate the release of GnRH, resulting in the optimal performance of gonadal physiological processes viz. production of steroid sex hormones and germ cells. However, studies linking kisspeptin to reproduction are yet scanty. Hence, studies exploring the upstream and downstream signaling pathways activated by kisspeptin concerning reproduction in an attempt to better understand the associated mechanisms of the regulatory activities of kisspeptin on reproduction are recommended. In addition, potential factors that may modulate kisspeptin activities may be useful in the management of infertility and perhaps, in the development of contraceptives for those who do not intend to achieve conception.

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Kisspeptin 对能量平衡和生殖的调节作用

下丘脑-垂体-性腺轴调节类固醇的生成和生殖细胞的形成，与生殖过程密切相关。然而，其他化学介质，如吻肽，也会影响这一轴心。Kisspeptin 是一种下丘脑神经肽，可调节该轴的功能，在能量平衡中也起着核心作用。本研究根据现有的文献证据，回顾了基斯肽对男性和女性生殖的影响及相关机制。Kisspeptin 及其神经元具有厌食活性，从而维持适当的能量平衡，以达到最佳的生殖功能。此外，它们还能刺激 GnRH 的释放，使性腺生理过程（即类固醇性激素和生殖细胞的产生）达到最佳状态。然而，将吻肽与生殖联系起来的研究还很少。因此，建议开展研究，探索吻肽激活的与生殖有关的上游和下游信号通路，以便更好地了解吻肽对生殖调节活动的相关机制。此外，可能调节吻肽活动的潜在因素可能有助于治疗不孕症，或许还有助于为无意受孕者开发避孕药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.