Milk fat globule EGF and factor V/VIII domain containing-mediated osteoimmunology in periodontal disease.

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE American journal of dentistry Pub Date : 2024-10-01

Ruonan Zhang, Shuang Peng, Lili Chen, Guangxun Zhu

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Abstract

Purpose: To review the literature on the relationship of milk fat globule EGF and factor V/VIII domain containing (MFGE8) in periodontal osteoimmunology and the clinical significance of MFGE8 in periodontal disease.

Methods: Two reviewers carried out a computer-based literature search using PubMed, Scopus, and Web of Science to identify papers published up to November 2023. The keywords used in the investigation were "MFGE8" and various words related to periodontal disease (periodontal, periodontitis, gingival, gingivitis, gingiva, and periodontium).

Results: MFGE8 plays a critical role in the etiology of periodontal disease via regulating pro-inflammatory cytokines and bone cells. In addition, MFGE8 may be applied as a diagnostic biomarker and a therapeutic target in periodontal disease.

Clinical significance: MFGE8-mediated periodontal osteoimmunology fills the vacant part of the pathogenesis in periodontal disease. This review provides a comprehensive perspective on the potential of MFGE8 in periodontal disease therapy.

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含乳脂球 EGF 和因子 V/VIII 结构域介导的牙周病骨免疫学。

目的：综述有关乳脂球EGF和含因子V/VIII结构域（MFGE8）在牙周骨免疫学中的关系以及MFGE8在牙周病中的临床意义的文献：两位审稿人使用 PubMed、Scopus 和 Web of Science 进行了计算机文献检索，以确定截至 2023 年 11 月发表的论文。调查中使用的关键词是 "MFGE8 "和各种与牙周病相关的词汇（periodontal、periodontitis、gingival、gingivitis、gingiva和periodontium）：结果：MFGE8 通过调节促炎细胞因子和骨细胞，在牙周病的病因学中起着至关重要的作用。此外，MFGE8 还可作为牙周病的诊断生物标志物和治疗靶点：临床意义：MFGE8介导的牙周骨免疫学填补了牙周病发病机制的空白。本综述从一个全面的角度探讨了 MFGE8 在牙周病治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of dentistry 医学-牙科与口腔外科

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： The American Journal of Dentistry, published by Mosher & Linder, Inc., provides peer-reviewed scientific articles with clinical significance for the general dental practitioner.