Impact of obesity on clinical outcomes of methicillin-susceptible Staphylococcus aureus bloodstream infections.

IF 4.1 2区 医学 Q2 MICROBIOLOGY Antimicrobial Agents and Chemotherapy Pub Date : 2024-11-06 Epub Date: 2024-09-26 DOI:10.1128/aac.00752-24
Anthony S Wasielewski, Anthony M Casapao, Christopher A Jankowski, Carmen L Isache, Malleswari Ravi, Ashlan J Kunz Coyne
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Abstract

Obesity affects over one-third of U.S. adults and complicates the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSI). A study at the University of Florida Health Centers compared clinical outcomes between 233 obese and non-obese patients receiving cefazolin for MSSA BSI. No significant differences were found in clinical success (81.9% vs 82.7%), mortality (7.2% vs 5.3%), or adverse events (3.6% vs 3.3%). However, obese patients took longer to clear blood cultures (4.62 vs 4.01 days, P = 0.017).

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肥胖对甲氧西林易感金黄色葡萄球菌血流感染临床结果的影响。
肥胖影响着三分之一以上的美国成年人,并使甲氧西林易感金黄色葡萄球菌(MSSA)血流感染(BSI)的治疗变得复杂。佛罗里达大学健康中心的一项研究比较了 233 名肥胖和非肥胖患者接受头孢唑啉治疗 MSSA BSI 的临床效果。在临床成功率(81.9% 对 82.7%)、死亡率(7.2% 对 5.3%)或不良事件(3.6% 对 3.3%)方面没有发现明显差异。不过,肥胖患者清除血液培养的时间更长(4.62 天 vs 4.01 天,P = 0.017)。
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来源期刊
CiteScore
10.00
自引率
8.20%
发文量
762
审稿时长
3 months
期刊介绍: Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.
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