Rapid and random-start endometrial preparation before outpatient hysteroscopic polypectomy in patients of perimenopausal age.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY Climacteric Pub Date : 2024-09-27 DOI:10.1080/13697137.2024.2404574

Andrea Etrusco, Antonio D'Amato, Vittorio Agrifoglio, Vito Chiantera, Giuseppe Russo, Tullio Golia D'Augè, Marco Monti, Gaetano Riemma, Antonio Simone Laganà, Andrea Giannini

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Abstract

Objective: This study aimed to assess the efficacy of randomly started oral dienogest/ethinylestradiol (DNG/EE) for swift endometrial preparation prior to outpatient hysteroscopic polypectomy in perimenopausal women.

Method: A multicenter, prospective, randomized controlled trial was conducted in university hospitals. Eighty perimenopausal women scheduled for outpatient hysteroscopic polypectomy between January 2023 and March 2024 were randomly assigned to either intervention (n = 40) or control (n = 40) groups. Exclusion criteria included concomitant endometrial pathologies, recent therapy and adnexal diseases. The intervention group received oral DNG/EE 2 mg/0.03 mg/day started on any day of the menstrual cycle for 14 days. The control group underwent polypectomy between menstrual cycle days 8 and 11 without pharmacological treatment.

Results: Pre-procedure (p < 0.001) and post-procedure (p < 0.001) endometrial thickness were significantly reduced in the intervention group, along with a higher incidence of hypotrophic/atrophic endometrial patterns (p < 0.001). Surgical parameters also differed significantly between groups.

Conclusion: DNG/EE treatment offers rapid, cost-effective endometrial preparation, enhancing surgical outcomes and patient satisfaction during outpatient polypectomy.

Trial registration: ClinicalTrials.gov NCT06316206.

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围绝经期患者在门诊宫腔镜息肉切除术前快速和随机启动子宫内膜准备。

研究目的本研究旨在评估围绝经期妇女在门诊宫腔镜息肉切除术前随机开始口服双烯雌酚/炔雌醇（DNG/EE）以迅速进行子宫内膜准备的疗效：在大学医院开展了一项多中心、前瞻性、随机对照试验。80名计划在2023年1月至2024年3月期间接受门诊宫腔镜息肉切除术的围绝经期妇女被随机分配到干预组（40人）或对照组（40人）。排除标准包括合并子宫内膜病变、近期接受过治疗和患有附件疾病。干预组在月经周期的任何一天开始口服 DNG/EE 2 毫克/0.03 毫克/天，持续 14 天。对照组在月经周期第 8 天和第 11 天之间接受息肉切除术，不进行药物治疗：手术前（P P P P 结论：DNG/EE治疗提供了快速、经济有效的子宫内膜准备，提高了门诊息肉切除术的手术效果和患者满意度：试验注册：ClinicalTrials.gov NCT06316206。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.