Cross-reactivity between thiuram disulfides and dithiocarbamates. A study of TETD and ZDEC using mouse models.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-09-28 DOI:10.1111/cod.14706

Christoffer Kursawe Larsen, Anders Boutrup Funch, Helen Vaher, Rebecca Kitt Davidson Lohmann, Mia Hamilton Jee, Jakob F B Schwensen, Claus Zachariae, Cecilia Svedman, Ola Bergendorff, Charlotte Menné Bonefeld, Jeanne D Johansen

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Abstract

Background: Rubber accelerators are used in the vulcanization of rubber. However, rubber accelerators for example tetraethylthiuram disulfide (TETD) and zinc diethyldithiocarbamate (ZDEC) may cause contact allergy. Concomitant reactions between ZDEC and TETD have been observed in patients which could be explained by co- or cross-reactivity.

Objectives: To investigate cross-reactivity between TETD and ZDEC and vice versa.

Methods: Groups of mice were sensitized with TETD or ZDEC based on reported EC3-values. Proliferation of lymphocytes were measured on day 5. To test cross-reactivity, mice were sensitized and challenged 3 weeks later with TETD or ZDEC. The inflammatory response was measured by changes in ear thickness and the proliferative response in CD4⁺ and CD8⁺ T cells in the submandibular and cervical draining lymph nodes.

Results: Sensitization of mice with doses of ZDEC 3%, TETD 5.6% or TETD 16.2% induced significant increased ear thickness and proliferation of CD4⁺ and CD8⁺ T cells. Challenge with ZDEC or TETD in these groups induced significant increased ear thickness. Challenge with ZDEC in mice sensitized to TETD 5.6% or TETD 16.2% induced significant increased proliferation of CD4⁺ and CD8⁺ T cells.

Conclusions: We show cross-reactivity between TETD and ZDEC. Patients sensitized to TETD or ZDEC should avoid exposure to both ZDEC and TETD.

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秋兰姆二硫化物与二硫代氨基甲酸酯之间的交叉反应。利用小鼠模型对 TETD 和 ZDEC 的研究。

背景：橡胶促进剂用于橡胶硫化。然而，橡胶促进剂（如二硫化四乙基秋兰姆（TETD）和二乙基二硫代氨基甲酸锌（ZDEC））可能会引起接触过敏。在患者中观察到 ZDEC 和 TETD 的并发反应，这可能是由于共反应或交叉反应引起的：研究 TETD 和 ZDEC 之间的交叉反应，反之亦然：方法：根据报告的 EC3 值，用 TETD 或 ZDEC 致敏一组小鼠。第 5 天测量淋巴细胞的增殖情况。为了测试交叉反应，对小鼠进行致敏，3 周后再用 TETD 或 ZDEC 对其进行挑战。炎症反应是通过耳厚度的变化以及颌下和颈部引流淋巴结中 CD4+ 和 CD8+ T 细胞的增殖反应来测量的：用剂量为 ZDEC 3%、TETD 5.6% 或 TETD 16.2% 的药物致敏小鼠，会导致耳厚显著增加，CD4+ 和 CD8+ T 细胞增殖。用 ZDEC 或 TETD 对这些组进行挑战会导致耳厚显著增加。对 TETD 5.6% 或 TETD 16.2% 敏感的小鼠用 ZDEC 进行挑战可诱导 CD4+ 和 CD8+ T 细胞增殖显著增加：我们发现TETD和ZDEC之间存在交叉反应。结论：我们发现 TETD 和 ZDEC 之间存在交叉反应。对 TETD 或 ZDEC 敏感的患者应避免同时接触 ZDEC 和 TETD。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.