Antithyroid Antibodies and Reproductive Parameters of Women with Hashimoto's Thyroiditis.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2024-09-25 DOI:10.1080/07435800.2024.2405147

Rafaela Silveira Ximenes de Souza, Alessandra Quintino-Moro, Denise Engelbrecht Zantut-Wittmann, Arlete Fernandes

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Abstract

Objectives/introduction: To evaluate the presence and concentration of antithyroid peroxidase (TPOAb) and antithyroglobulin (TGAb) antibodies at the onset of Hashimoto's Thyroiditis (HT) and their association with disease characteristics and reproductive parameters before and after diagnosis.

Methods: This is a cross-sectional study with 65 women with HT followed in an outpatient clinic. The data was collected by interviews and review of medical records. The variables were characteristics of the disease; TPOAb and TGAb measurements; pregnancies; live children; premature births; pregnancy losses and infertility. We used the chi-square or Fisher's exact tests, the Mann-Whitney test and the Spearman correlation. The significance level was set at 5%.

Results: The mean age at diagnosis was 38 (SD ± 11.1) years and the duration of the disease was 7.5 (SD ± 5.3) years; 46% of the women reported infertility periods. 59/65 (90.7%) women had TPOAb and 42 (64.6%) had TGAb antibodies. Comparison between the groups with and without TPOAb or TGAb showed no differences between all variables studied. We found positive correlations between TPOAb concentration and preterm births and thyroid volume; and TGAb concentration was positively correlated with age.

Conclusion: The presence of autoantibodies did not influence reproductive parameters; TPOAb concentration was correlated with premature births and thyroid volume.

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桥本氏甲状腺炎妇女的抗甲状腺抗体和生殖参数

目的/简介：评估桥本氏甲状腺炎（HT）发病时抗甲状腺过氧化物酶（TPOAb）和抗甲状腺球蛋白（TGAb）抗体的存在和浓度，以及它们与疾病特征和诊断前后生殖参数的关系：这是一项横断面研究，研究对象为门诊随访的65名桥本氏甲状腺炎女性患者。数据通过访谈和查阅病历收集。变量包括疾病特征、TPOAb 和 TGAb 测量值、妊娠、活产、早产、妊娠失败和不孕。我们使用了卡方检验或费雪精确检验、曼-惠特尼检验和斯皮尔曼相关检验。显著性水平设定为 5%：确诊时的平均年龄为 38 岁（标准差 ± 11.1），病程为 7.5 年（标准差 ± 5.3）；46% 的妇女报告有不孕期。59/65（90.7%）名妇女有 TPOAb 抗体，42（64.6%）名妇女有 TGAb 抗体。有 TPOAb 或 TGAb 的组别与没有 TPOAb 或 TGAb 的组别的比较显示，所有研究变量之间均无差异。我们发现，TPOAb浓度与早产和甲状腺体积呈正相关；TGAb浓度与年龄呈正相关：结论：自身抗体的存在不会影响生殖参数；TPOAb浓度与早产和甲状腺体积相关。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.

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