The visceral fat area/subcutaneous fat area ratio is positively associated with carotid atherosclerosis in patients with type 2 diabetes mellitus.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Endocrine Connections Pub Date : 2024-11-14 Print Date: 2024-12-01 DOI:10.1530/EC-24-0412

Dandan Hu, Xiangguo Cong, Beibei Gao, Ying Wu, Qiong Shen, Lei Chen

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Abstract

Background: Evidence has demonstrated that visceral fat area (VFA) and subcutaneous fat area (SFA) have different influences on cardiovascular disease (CVD) risk in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the relationship between the visceral fat area (VFA), the subcutaneous fat area (SFA) ratio (V/S), and carotid atherosclerosis (CAS) in patients with T2DM.

Methods: From January 2018 to May 2023, 1838 patients with T2DM admitted to the National Metabolic Management Centre in our hospital were assigned to two groups based on comorbid CAS. Dual bioelectrical impedance analysis was used to measure the VAF and SFA, and the V/S was calculated. Patient characteristics and serum biochemical indices were compared between groups. Factors influencing comorbid CAS were determined, and correlations between V/S and other clinical indices were analyzed.

Results: The group with comorbid CAS included 858 individuals and 980 without comorbid CAS. Those with comorbid CAS were older and had a longer disease duration, more significant systolic blood pressure, and greater V/S. The proportions of patients with comorbid hypertension increased significantly with the V/S ratio. The V/S ratio positively correlated with triglyceride (TG), low-density lipoprotein cholesterol levels, and waist circumference. According to binary logistic regression analysis, V/S was an independent risk factor for CAS.

Conclusion: Elevated V/S is an independent risk factor for CAS in patients with T2DM.

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2 型糖尿病患者的内脏脂肪面积/皮下脂肪面积比与颈动脉粥样硬化呈正相关。

背景：有证据表明，内脏脂肪面积（VFA）和皮下脂肪面积（SFA）对2型糖尿病（T2DM）患者的心血管疾病（CVD）风险具有不同的影响。我们旨在研究T2DM患者内脏脂肪面积（VFA）与皮下脂肪面积（SFA）比值（V/S）与颈动脉粥样硬化（CAS）之间的关系：2018年1月至2023年5月，根据合并CAS的情况，将我院国家代谢管理中心收治的1838名T2DM患者分为两组。采用双生物电阻抗分析法测量VAF和SFA，并计算V/S。比较两组患者的特征和血清生化指标。确定了合并 CAS 的影响因素，并分析了 V/S 与其他临床指标之间的相关性：结果：合并 CAS 组包括 858 人，无合并 CAS 组包括 980 人。合并 CAS 的患者年龄更大、病程更长、收缩压更高、V/S 更大。合并高血压的患者比例随 V/S 比值的升高而显著增加。V/S 比值与甘油三酯（TG）、低密度脂蛋白胆固醇水平和腰围呈正相关。根据二元逻辑回归分析，V/S 是 CAS 的独立危险因素：结论：V/S升高是T2DM患者发生CAS的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Connections Medicine-Internal Medicine

CiteScore

5.00

自引率

3.40%

发文量

361

审稿时长

6 weeks

期刊介绍： Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.