Dynamics of serum cytokines in preeclampsia.

IF 2.2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY European cytokine network Pub Date : 2024-09-01 DOI:10.1684/ecn.2024.0497
Almagul Kurmanova, Gulfairuz Urazbayeva, Laura Kayupova, Damilya Salimbaeva, Nurzhamal Dzhardemalieva
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Abstract

The aim of the present study was to evaluate the diagnostic significance of the dynamics of cytokines and growth factors during pregnancy with and without preeclampsia. The study included 168 pregnant women at risk of hypertensive disorders. The levels of biomarkers of all pregnant women were studied at 12-16 weeks, 28-30 weeks and 36-38 weeks. These included cytokines (tumour necrosis factor-α, interferon-, γinterleukin-4) and growth factors (placental growth factor, vascular endothelial growth factor). All pregnant women were divided into two groups: 124 patients with preeclampsia and 44 without preeclampsia (control group). In patients with preeclampsia, an increase in the level of tumour necrosis factorα- was observed, compared with the control group: a 6.1-fold increase at 12-16 weeks and a 5.9-fold increase at 36-38 weeks. The level of interferon-γ was also increased, by 44.3% in the first trimester of pregnancy and by 46.8% at 28-30 weeks, compared to the control group. The level of interleukin-4 did not significantly differ between the studied groups. The level of placental growth factor was reduced in pregnant women with preeclampsia at all stages of gestation, and at 28-30 weeks was reduced by 67.9% compared to the control group. The level of vascular endothelial growth factor was also reduced, by 75%, compared with the control group. An increase in the level of pro-inflammatory cytokines and decrease in growth factors may therefore be considered as potential predictors of the development of preeclampsia, and evaluation of these factors may be advocated in pregnant women with risk factors of preeclampsia.

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子痫前期血清细胞因子的动态变化。
本研究旨在评估子痫前期和非子痫前期孕妇体内细胞因子和生长因子动态的诊断意义。研究对象包括 168 名有高血压疾病风险的孕妇。在怀孕 12-16 周、28-30 周和 36-38 周时,对所有孕妇的生物标志物水平进行了研究。这些指标包括细胞因子(肿瘤坏死因子-α、干扰素、γ 白细胞介素-4)和生长因子(胎盘生长因子、血管内皮生长因子)。所有孕妇被分为两组:124 名先兆子痫患者和 44 名无先兆子痫患者(对照组)。与对照组相比,子痫前期患者体内的肿瘤坏死因子α-水平有所上升:12-16 周时上升 6.1 倍,36-38 周时上升 5.9 倍。干扰素-γ的水平也有所上升,与对照组相比,在妊娠头三个月上升了44.3%,在妊娠28-30周上升了46.8%。研究组之间的白细胞介素-4水平没有明显差异。患有子痫前期的孕妇在妊娠的各个阶段胎盘生长因子的水平都有所降低,与对照组相比,在妊娠 28-30 周时降低了 67.9%。与对照组相比,血管内皮生长因子的水平也降低了 75%。因此,促炎症细胞因子水平的升高和生长因子水平的降低可被视为子痫前期发生的潜在预测因素,建议有子痫前期风险因素的孕妇对这些因素进行评估。
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来源期刊
European cytokine network
European cytokine network 生物-免疫学
CiteScore
5.70
自引率
0.00%
发文量
5
审稿时长
6 months
期刊介绍: The journal that brings together all areas of work involving cytokines. European Cytokine Network is an electronic journal that publishes original articles and abstracts every quarter to provide an essential bridge between researchers and clinicians with an interest in this cutting-edge field. The journal has become a must-read for specialists in the field thanks to its swift publication and international circulation. The journal is referenced in several databases, including Medline, which is testament to its scientific quality.
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