Eyyup Murat Karakurt, Yan Huang, Yuksel Cetin, Alper Incesu, Huseyin Demirtas, Mehmet Kaya, Yasemin Yildizhan, Merve Tosun, Gulsah Akbas
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引用次数: 0
Abstract
Titanium-Niobium (TiNb) alloys are commonly employed in a number of implantable devices, yet concerns exist regarding their use in implantology owing to the biomechanical mismatch between the implant and the host tissue. Therefore, to balance the mechanical performance of the load-bearing implant with bone, TiNb alloys with differing porosities were fabricated by powder metallurgy combined with spacer material. Microstructures and phase constituents were characterized with energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The mechanical properties were tested by uniaxial compression, and the corrosion performance was determined via a potentiodynamic polarization experiment. To evaluate a highly matched potential implant with the host, biocompatibilities such as cell viability and proliferation rate, fibronectin adsorption, plasmid-DNA interaction, and an SEM micrograph showing the cell morphology were examined in detail. The results showed that the alloys displayed open and closed pores with a uniform pore size and distribution, which allowed for cell adherence and other cellular activities. The alloys with low porosity displayed compressive strength between 618 MPa and 1295 MPa, while the alloys with high porosity showed significantly lower strength, ranging from 48 MPa to 331 MPa. The biological evaluation of the alloys demonstrated good cell attachment and proliferation rates.
钛铌合金(TiNb)通常被用于许多植入设备中,但由于植入物与宿主组织之间的生物力学不匹配,人们对其在植入学中的应用存在担忧。因此,为了平衡承重植入体与骨骼之间的机械性能,我们采用粉末冶金法结合间隔材料制造了具有不同孔隙率的钛铌合金。利用能量色散光谱(EDS)、扫描电子显微镜(SEM)和 X 射线衍射(XRD)对微观结构和相组成进行了表征。通过单轴压缩测试了其机械性能,并通过电位极化实验确定了其腐蚀性能。为了评估与宿主高度匹配的潜在植入物,详细研究了生物相容性,如细胞活力和增殖率、纤维连接蛋白吸附、质粒与 DNA 的相互作用,以及显示细胞形态的 SEM 显微照片。结果表明,合金显示出孔隙大小和分布均匀的开放式和封闭式孔隙,有利于细胞粘附和其他细胞活动。低孔隙率合金的抗压强度介于 618 兆帕和 1295 兆帕之间,而高孔隙率合金的抗压强度明显较低,介于 48 兆帕和 331 兆帕之间。对合金进行的生物学评估表明,其细胞附着和增殖率良好。
期刊介绍:
Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.