Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report.

IF 2.9 Q1 OPHTHALMOLOGY Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-09-30 DOI:10.1186/s12348-024-00433-x

Langxuan Yuan, Yuchen Li, Hanze Zhang, Yucen Hou, Qianyan Kang, Jianqin Lei

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Abstract

Background: To report a case of Bilateral Purtscher-like retinopathy associated with DRESS syndrome managed with ocular and systemic treatments.

Case presentation: A 29-year-old healthy female developed multi-organ (cutaneous, hematologic, renal and hepatic) disfunction and profound vision loss 1 month after Human papillomavirus vaccine injection. At the first presentation, her visual acuity was counting fingers in both eyes. Fundus exam showed remarkable cotton-wool spots, retinal hemorrhages and macular edema. She was diagnosed DRESS syndrome and Purtscher-like retinopathy and treated with intravitreal injection of ranibizumab, systemic steroids anticoagulants, and plasma exchange. The patient finally recovered from this life-threatening condition but left with permanent visual damage.

Conclusion: Purtscher-like retinopathy could be complicated by DRESS syndrome which is usually considered a type IV hypersensitivity reaction.

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与 DRESS 综合征相关的双侧脓肿样视网膜病变：病例报告。

背景：报告一例与 DRESS 综合征相关的双侧紫癜样视网膜病变病例，该病例通过眼部和全身治疗得到了控制：一名 29 岁的健康女性在注射人乳头瘤病毒疫苗 1 个月后出现多器官（皮肤、血液、肾脏和肝脏）功能障碍和视力严重下降。首次就诊时，她的双眼视力均为数指。眼底检查显示明显的棉絮斑、视网膜出血和黄斑水肿。她被诊断为 DRESS 综合征和 Purtscher 类视网膜病变，并接受了雷尼珠单抗玻璃体内注射、全身类固醇抗凝剂和血浆置换治疗。患者最终从这一危及生命的疾病中康复，但留下了永久性视力损伤：结论：脓毒症样视网膜病变可能并发 DRESS 综合征，而 DRESS 综合征通常被认为是 IV 型超敏反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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