{"title":"Two new compounds from the capitula of <i>Chrysanthemum morifolium</i> cv. Fubaiju.","authors":"Jin-Lin Chen, Yue-Hao Huang, Si-Yu Yang, Xue-Fang Zhuo, Yao-Lan Li, Yu-Bo Zhang, Jun-Jie Zhong, Guo-Cai Wang","doi":"10.1080/14786419.2024.2409981","DOIUrl":null,"url":null,"abstract":"<p><p>A new germacrane-type sesquiterpenoid (<b>1</b>) and a new alkamide (<b>2</b>), as well as six known compounds (<b>3</b>-<b>8</b>) were isolated from the capitula of <i>Chrysanthemum morifolium</i> cv. Fubaiju. The new structures were elucidated by comprehensive spectroscopic analysis and quantum chemical calculations. The known structures were characterised <i>via</i> 1D NMR data compared with the already existing literature data. Among the isolates, compound <b>5</b> showed inhibitory activity against human lung cancer A549 cells and human hepatoma HepG2 cells with the IC<sub>50</sub> values of 19.50 ± 1.23 and 23.24 ± 1.30 µM, respectively, and compound <b>8</b> exhibited inhibitory effect on RSV infection with IC<sub>50</sub> value of 12.50 ± 1.02 µM.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2409981","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A new germacrane-type sesquiterpenoid (1) and a new alkamide (2), as well as six known compounds (3-8) were isolated from the capitula of Chrysanthemum morifolium cv. Fubaiju. The new structures were elucidated by comprehensive spectroscopic analysis and quantum chemical calculations. The known structures were characterised via 1D NMR data compared with the already existing literature data. Among the isolates, compound 5 showed inhibitory activity against human lung cancer A549 cells and human hepatoma HepG2 cells with the IC50 values of 19.50 ± 1.23 and 23.24 ± 1.30 µM, respectively, and compound 8 exhibited inhibitory effect on RSV infection with IC50 value of 12.50 ± 1.02 µM.
期刊介绍:
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.