Effectiveness of influenza vaccines in preventing acute cardiovascular events within 1 year in Beijing, China.

IF 6.9 1区 医学 Q1 IMMUNOLOGY NPJ Vaccines Pub Date : 2024-09-28 DOI:10.1038/s41541-024-00969-y
Yuan Ma, Feng Lu, Luodan Suo, Wei Li, Jie Qian, Tianqi Wang, Min Lv, Jiang Wu, Weizhong Yang, Moning Guo, Juan Li, Luzhao Feng
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Abstract

Controversies persist about the protective effects of vaccines against acute cardiovascular events. Using electronic medical records from hospitals and influenza vaccine administration data in Beijing, China, we studied individuals vaccinated between January 1, 2016, and December 31, 2018, who experienced at least one acute cardiovascular event within two years. A self-controlled case series design calculated the relative incidence (RI) and 95% confidence interval (CI) of acute cardiovascular events within one year after vaccination. Among 1647 participants (median age: 65 years, 38.43% female), the risk of events 29-365 days post-vaccination was 0.76 times the baseline level (RI: 0.76; 95% CI: 0.68-0.84). The protective effect was more pronounced in younger participants (P = 0.043) and those without cardiovascular history (P < 0.001), while acute respiratory infection (P = 0.986) and vaccination frequency (P = 0.272) had no impact. Influenza vaccines offer protection against acute cardiovascular events for at least one year, suggesting potential for cardiovascular disease prevention.

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在中国北京,流感疫苗在 1 年内预防急性心血管事件的效果。
疫苗对急性心血管事件的保护作用一直存在争议。利用中国北京医院的电子病历和流感疫苗接种数据,我们研究了在 2016 年 1 月 1 日至 2018 年 12 月 31 日期间接种疫苗、两年内至少发生过一次急性心血管事件的人群。我们采用自控病例系列设计计算了接种疫苗后一年内急性心血管事件的相对发生率(RI)和 95% 置信区间(CI)。在 1647 名参与者(中位年龄:65 岁,38.43% 为女性)中,接种疫苗后 29-365 天内发生事件的风险是基线水平的 0.76 倍(RI:0.76;95% CI:0.68-0.84)。这种保护作用在年轻参与者(P = 0.043)和无心血管病史者(P = 0.043)中更为明显。
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来源期刊
NPJ Vaccines
NPJ Vaccines Immunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍: Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.
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