Targeted radionuclide therapy for patients with CNS metastasis: overlooked potential?

IF 16.4 1区 医学 Q1 CLINICAL NEUROLOGY Neuro-oncology Pub Date : 2024-10-01 DOI:10.1093/neuonc/noae192
Emilie Le Rhun, Nathalie L Albert, Martin Hüllner, Enrico Franceschi, Norbert Galldiks, Philipp Karschnia, Giuseppe Minniti, Tobias Weiss, Matthias Preusser, Benjamin M Ellingson, Michael Weller
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Abstract

Targeted radionuclide therapy is an emerging therapeutic concept for metastatic cancer that can be considered if a tumor can be delineated by nuclear medicine imaging and also targeted based on expression of a particular target (thera-nostics). This mode of treatment can also compete with or supplement conventional radiotherapy e.g., if MRI does not fully capture the extent of disease, including microscopic metastases. Targeted radionuclide therapy for patients with thyroid cancer, with certain somatostatin receptor 2-expressing tumors and with prostate-specific membrane antigen (PSMA)-expressing prostate cancer are approved, and numerous approaches of targeted radionuclide therapy for patients with metastatic cancer are in development (e.g. using fibroblast activation protein (FAP) as a target). Although brain metastases are rare in the cancers with approved targeted radionuclide therapies, there is no a priori reason to assume that such treatments would not be effective against brain metastases if the targets are expressed and not shielded by the blood brain barrier. Here, we discuss the current state of the art and opportunities of targeted radionuclide therapies for patients with brain and leptomeningeal metastases.

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针对中枢神经系统转移患者的放射性核素靶向治疗:被忽视的潜力?
靶向放射性核素疗法是治疗转移性癌症的一种新兴治疗理念,如果肿瘤可以通过核医学成像确定,并根据特定靶点的表达情况进行靶向治疗(thera-nostics),就可以考虑采用这种疗法。如果核磁共振成像不能完全捕捉到包括微小转移灶在内的疾病范围,这种治疗模式也可以与传统放疗竞争或作为补充。针对甲状腺癌、某些表达体生长抑素受体 2 的肿瘤和表达前列腺特异性膜抗原(PSMA)的前列腺癌患者的放射性核素靶向治疗已获得批准,针对转移性癌症患者的多种放射性核素靶向治疗方法(如使用成纤维细胞活化蛋白(FAP)作为靶点)也在开发中。虽然在已获批放射性核素靶向疗法的癌症中,脑转移是罕见的,但没有先验的理由假定,如果靶点表达且未被血脑屏障屏蔽,这种疗法就不会对脑转移有效。在此,我们将讨论针对脑转移瘤和脑膜转移瘤患者的放射性核素靶向疗法的技术现状和机遇。
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来源期刊
Neuro-oncology
Neuro-oncology 医学-临床神经学
CiteScore
27.20
自引率
6.30%
发文量
1434
审稿时长
3-8 weeks
期刊介绍: Neuro-Oncology, the official journal of the Society for Neuro-Oncology, has been published monthly since January 2010. Affiliated with the Japan Society for Neuro-Oncology and the European Association of Neuro-Oncology, it is a global leader in the field. The journal is committed to swiftly disseminating high-quality information across all areas of neuro-oncology. It features peer-reviewed articles, reviews, symposia on various topics, abstracts from annual meetings, and updates from neuro-oncology societies worldwide.
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