Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta-analyses.

IF 17.5 1区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Periodontology 2000 Pub Date : 2024-09-30 DOI:10.1111/prd.12609
Sayed Ahmad Manoetjer Siawasch, Jize Yu, Ana B Castro, Rutger Dhondt, Wim Teughels, Andy Temmerman, Marc Quirynen
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Abstract

In order to evaluate the therapeutic advantages of various autologous platelet concentrates (APC) as a single biomaterial during alveolar ridge preservation (ARP), a systematic review with meta-analyses was conducted. PubMed, EMBASE, Web of Science, and Scopus were screened for randomized controlled trials (RCTs) that were released prior to 2024. The selected papers compared an APC with either unassisted healing (blood clot) or another biomaterial during ARP (third molars were not included). The outcome parameters included alveolar bone dimension alterations, soft tissue healing, and post-op pain intensity. The search yielded 35 papers (33 studies), one applying platelet-rich plasma (PRP), six using plasma rich in growth factors (PRGF), and 28 using leukocyte- and platelet-rich fibrin (L-PRF). These studies showed a large heterogeneity (e.g., outcome parameters, timing, surgical approach, and inclusion criteria), which hindered drawing strong conclusions. In most studies, however, ARP with PRP, PRGF, and L-PRF alone produced faster soft tissue healing, less post-extraction pain, less alveolar ridge resorption, more socket bone fill, and a higher bone density when compared to unassisted (spontaneous) healing. The ultimate benefit appears to be significantly influenced by the surgical approach. Limited literature exists comparing APC with other biomaterials for ARP, resulting in inconclusive data. APC application for ARP is a promising strategy to improve soft and hard tissue healing and reduce post-extraction pain.

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用于牙槽嵴保留的自体血小板浓缩物:系统回顾与荟萃分析。
为了评估各种自体血小板浓缩物(APC)作为单一生物材料在牙槽脊保存(ARP)过程中的治疗优势,我们进行了一项系统性综述和荟萃分析。在 PubMed、EMBASE、Web of Science 和 Scopus 中筛选了 2024 年之前发布的随机对照试验 (RCT)。所选论文将 APC 与 ARP 期间的无辅助愈合(血块)或其他生物材料进行了比较(不包括第三磨牙)。结果参数包括牙槽骨尺寸改变、软组织愈合和术后疼痛强度。搜索共获得 35 篇论文(33 项研究),其中 1 篇采用富血小板血浆 (PRP),6 篇采用富含生长因子的血浆 (PRGF),28 篇采用白细胞和富血小板纤维蛋白 (L-PRF)。这些研究显示出很大的异质性(如结果参数、时间、手术方法和纳入标准),这阻碍了得出有力的结论。不过,在大多数研究中,与无辅助(自发)愈合相比,单独使用 PRP、PRGF 和 L-PRF 的 ARP 能加快软组织愈合,减轻拔牙后疼痛,减少牙槽嵴吸收,增加牙槽窝骨填充,提高骨密度。最终的益处似乎在很大程度上受到手术方法的影响。将 APC 与其他用于 ARP 的生物材料进行比较的文献有限,因此没有定论。将 APC 应用于 ARP 是一种很有前景的策略,可以改善软组织和硬组织的愈合,减轻拔牙后的疼痛。
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来源期刊
Periodontology 2000
Periodontology 2000 医学-牙科与口腔外科
CiteScore
34.10
自引率
2.20%
发文量
62
审稿时长
>12 weeks
期刊介绍: Periodontology 2000 is a series of monographs designed for periodontists and general practitioners interested in periodontics. The editorial board selects significant topics and distinguished scientists and clinicians for each monograph. Serving as a valuable supplement to existing periodontal journals, three monographs are published annually, contributing specialized insights to the field.
期刊最新文献
Periodontal disease: A systemic condition. Periodontal diseases in Africa. Autogenous platelet concentrates for treatment of intrabony defects—A systematic review with meta‐analysis Orthodontic management of uneven gingival margins in patients with healthy or reduced periodontium to improve smile aesthetics. Autologous platelet concentrates in root coverage procedures.
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