The parallel narrative of RGF/GLV/CLEL peptide signalling.

Abstract

Plant peptide families share distinct characteristics, and many members are in homologous signalling pathways controlling development and responses to external signals. The root meristem growth factor (RGF) peptides/GOLVEN (GLV)/CLAVATA3-ESR-related like (CLEL) are a family of short signalling peptides that are derived from a precursor protein and undergo post-translational modifications. Their role in root meristem development is well established and recent efforts have identified subtilase processing pathways and several downstream signalling components. This discovery has enabled the convergence of previously distinct pathways and enhanced our understanding of plant developmental processes. Here, we review the structure-function relationship of RGF peptides, the post-translational modification pathways, and the downstream signalling mechanisms and highlight components of these pathways that are known in non-RGF-mediated pathways.