Associations of ocular anterior segment structures with sex and age: the Yamagata study (Funagata).

IF 2.1 3区 医学 Q2 OPHTHALMOLOGY Japanese Journal of Ophthalmology Pub Date : 2024-10-02 DOI:10.1007/s10384-024-01126-7
Hiroyuki Namba, Naoyuki Maeda, Makoto Tsukamoto, Hiroshi Utsunomiya, Yutaka Kaneko, Koichi Nishitsuka, Hidetoshi Yamashita, Yasuyuki Ohta, Tomohiko Usui, Masahiko Sugimoto
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Abstract

Purpose: To investigate the associations of tomographic parameters in anterior segment optical coherence tomography (AS-OCT) with sex and age in a cohort study.

Study design: A cohort design.

Materials and methods: AS-OCT data from 391 Japanese participants aged ≥ 35 years were obtained using swept-source OCT. In the cornea, the keratometric power at the flat (Kf) and steep (Ks) meridians, maximum keratometric power (Kmax), keratometric cylinder, spherical power, regular astigmatism, asymmetry, higher-order irregularity (HOI) from the anterior and posterior surfaces, and the central and thinnest corneal thicknesses were evaluated. Also, anterior chamber depth (ACD), lens thickness, crystalline lens rise (CLR), and nasal and temporal angle opening distances at 500 μm from the scleral spur (AOD500) were assessed. Sex differences and age-related changes were analyzed.

Results: Women exhibited higher anterior Kf, Ks, and Kmax and lower posterior Kf, Ks, and Kmax than men. The ACD and nasal/temporal AOD500 were shorter in women than in men. The CLR was higher in women, whereas the lens thickness did not differ between the sexes, indicating a more anteriorly positioned lens in women. Age-related changes included increased anterior/posterior HOI, increased lens thickness and CLR resulting in decreased ACD and AOD500.

Conclusion: This study reveals sex-related differences in corneal shape, anterior chamber conformation, and lens position, as well as age-related changes in tomographic parameters. ACD, CLR, nasal and temporal AOD500 showed significant sex differences in the 50-70 s, whereas lens thickness showed no difference.

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眼球前段结构与性别和年龄的关系:山形研究(船形)。
目的:在一项队列研究中调查前段光学相干断层成像(AS-OCT)的断层参数与性别和年龄的关系:材料与方法:队列研究:使用扫源 OCT 获取了 391 名年龄≥ 35 岁的日本参与者的 AS-OCT 数据。评估了角膜平经(Kf)和陡经(Ks)的角膜测力、最大角膜测力(Kmax)、角膜柱面、球面力、规则散光、不对称、前后表面的高阶不规则度(HOI)以及角膜中央和最薄厚度。此外,还评估了前房深度(ACD)、晶状体厚度、晶状体上升(CLR)以及距巩膜距 500 μm 处的鼻角和颞角开口距离(AOD500)。分析了性别差异和与年龄有关的变化:结果:与男性相比,女性的前 Kf、Ks 和 Kmax 较高,而后 Kf、Ks 和 Kmax 较低。女性的 ACD 和鼻/颞 AOD500 比男性短。女性的CLR更高,而晶状体厚度在性别上没有差异,这表明女性的晶状体位置更靠前。与年龄相关的变化包括前后HOI增加、晶状体厚度和CLR增加,导致ACD和AOD500下降:这项研究揭示了角膜形状、前房构型和晶状体位置的性别差异,以及与年龄相关的层析成像参数变化。ACD、CLR、鼻部和颞部 AOD500 在 50-70 秒内显示出显著的性别差异,而晶状体厚度则无差异。
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来源期刊
CiteScore
4.80
自引率
8.30%
发文量
65
审稿时长
6-12 weeks
期刊介绍: The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.
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