Application of carbonic anhydrase IX in sporadic hemangioblastoma of the central nervous system and hemangioblastoma associated with von Hippel-Lindau disease.

IF 0.8 4区 医学 Q4 CLINICAL NEUROLOGY Clinical Neuropathology Pub Date : 2024-10-02 DOI:10.5414/NP301620
Xue Chen, Xiaoxiang Gao, Jiaqi Bo, Haixia Bi, Haoyang Zhang, Yuting Liu, Jie Yu, Xianghua Yi, Fei Wang, Suxia Zhang, Yu Zeng
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Abstract

Objective: This research aims to examine the expression of carbonic anhydrase IX (CAIX) protein in hemangioblastoma of the central nervous system and its potential application in pathological diagnosis and differential diagnosis.

Materials and methods: Immunohistochemistry was used to identify the expression of CAIX and the α-inhibin protein. The sensitivity and specificity of CAIX and α-inhibin for identifying hemangioblastoma of the central nervous system were compared. In addition, 86 patients with meningiomas were gathered to detect CAIX protein expression. Hemangioblastoma and angiomatous, microcystic the two subtypes of meningiomas, were compared for CAIX and EMA protein expression.

Results: In hemangioblastoma, there were significant differences in the median positive percentage and staining intensity of CAIX and α-inhibin (p < 0.05). There was no discernible difference in the expression of the CAIX protein between sporadic hemangioblastoma of the central nervous system and those linked to von Hippel‒Lindau disease. In comparison to angiomatous and microcystic meningiomas, the positive rate of CAIX in hemangioblastomas was substantially greater (p < 0.001). The expression of EMA in microcystic meningioma (6/6) and angiomatous meningioma (17/17) was significantly different from hemangioblastoma (0/30) (p < 0.0001).

Conclusion: Hemangioblastoma might be diagnosed with high specificity and sensitivity through CAIX immunohistochemistry. The combination of CAIX with EMA is useful for the diagnosis and differential diagnosis of hemangioblastoma.

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碳酸酐酶 IX 在中枢神经系统散发性血管母细胞瘤和与 von Hippel-Lindau 病相关的血管母细胞瘤中的应用。
研究目的本研究旨在探讨碳酸酐酶 IX(CAIX)蛋白在中枢神经系统血管母细胞瘤中的表达及其在病理诊断和鉴别诊断中的潜在应用:采用免疫组织化学方法鉴定 CAIX 和 α 抑制蛋白的表达。比较了 CAIX 和 α-抑制蛋白在鉴别中枢神经系统血管母细胞瘤方面的敏感性和特异性。此外,还收集了 86 例脑膜瘤患者的样本,以检测 CAIX 蛋白的表达。比较了血管母细胞瘤和血管瘤、微囊性脑膜瘤这两种亚型的 CAIX 和 EMA 蛋白表达情况:在血管母细胞瘤中,CAIX和α-抑制素的中位阳性率和染色强度存在显著差异(p < 0.05)。中枢神经系统散发性血管母细胞瘤和与冯-希佩尔-林道病有关的血管母细胞瘤在 CAIX 蛋白的表达上没有明显差异。与血管瘤和微囊脑膜瘤相比,血管母细胞瘤的 CAIX 阳性率要高得多(p < 0.001)。微囊型脑膜瘤(6/6)和血管瘤型脑膜瘤(17/17)中 EMA 的表达与血管母细胞瘤(0/30)有显著差异(P < 0.0001):结论:通过CAIX免疫组化可诊断出特异性和灵敏度较高的血管母细胞瘤。结论:通过 CAIX 免疫组化可对血管母细胞瘤进行高特异性和高敏感性诊断,CAIX 与 EMA 的结合有助于血管母细胞瘤的诊断和鉴别诊断。
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来源期刊
Clinical Neuropathology
Clinical Neuropathology 医学-病理学
CiteScore
1.60
自引率
0.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.
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