Central nervous tissue in ovarian mature teratoma: A neuropathological study of 101 resected tumors.

IF 1.3 4区 医学 Q4 CLINICAL NEUROLOGY Neuropathology Pub Date : 2024-10-03 DOI:10.1111/neup.13000
Masayuki Shintaku
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Abstract

Ovarian mature teratomas frequently contain central nervous system (CNS) tissue that often exhibits a variety of neuropathologic alterations. The author systematically examined the changes seen in CNS tissue from a series of 251 cases of resected ovarian mature teratomas. A total of 101 (40.2%) samples contained CNS tissue in varying amounts. The principal pathologic findings in the CNS tissue from ovarian mature teratomas were as follows: (i) CNS tissue tended to form a relatively thin, undulating, plate-like structure that comprised the walls or septa of cystic tumors; (ii) most neurons were small or medium sized, and no CD34-positive "ramifying cells" were observed; (iii) cytoplasmic processes of some astrocytes closely surrounded the walls of capillaries, suggesting formation of a blood-brain barrier; (iv) some ependymal cells exhibited a columnar shape and showed a pseudostratified arrangement, and these cells extended thick basal cytoplasmic processes into the neuropil; (v) a few choroid plexus epithelial cells showed melanin deposition, tubular transformation, or oncocytic changes; (vi) hamartoma-like hyperplasia of arachnoid cells was noted beneath skin tissue; (vii) some CNS tissue showed formation of cerebral cortical structures exhibiting "gyration" with incompletely layered structures, and disruption of the glia limitans with spillage of cortical tissue into the "subarachnoid" space was also observed; and (viii) in the well-formed cerebellar cortex, dendrites of Purkinje cells exhibited varied dysmorphic changes. These neuropathologic observations should lead to a deeper understanding of the pathogenesis of various lesions in the brain.

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卵巢成熟畸胎瘤的中枢神经组织:101 例切除肿瘤的神经病理学研究。
卵巢成熟畸胎瘤中经常含有中枢神经系统(CNS)组织,这些组织通常会出现各种神经病理学改变。作者对一系列 251 例切除的卵巢成熟畸胎瘤中的中枢神经系统组织变化进行了系统研究。共有 101 个样本(40.2%)含有不同数量的中枢神经系统组织。卵巢成熟畸胎瘤中枢神经系统组织的主要病理结果如下:(i) 中枢神经系统组织往往形成相对较薄、起伏不定的板状结构,构成囊性肿瘤的壁或隔膜;(ii) 大多数神经元为小型或中型,未观察到 CD34 阳性的 "柱状细胞";(iii) 一些星形胶质细胞的胞浆突起紧紧包裹着毛细血管壁,表明形成了血脑屏障;(iv) 一些上皮细胞呈柱状,呈假增生排列,这些细胞将粗大的基底胞浆突起伸入神经鞘内;(v) 少数脉络丛上皮细胞出现黑色素沉积、管状变或肿瘤细胞变化;(vi) 皮肤组织下出现蛛网膜细胞仓瘤样增生;(vii) 一些中枢神经系统组织显示大脑皮层结构的形成呈现 "回旋 "状,结构分层不完整,还观察到边缘胶质细胞的破坏,皮层组织溢出到 "蛛网膜下腔";以及 (viii) 在形成良好的小脑皮层中,浦肯野细胞的树突表现出不同的畸形变化。这些神经病理学观察结果应有助于加深对大脑各种病变发病机制的理解。
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来源期刊
Neuropathology
Neuropathology 医学-病理学
CiteScore
4.10
自引率
4.30%
发文量
105
审稿时长
6-12 weeks
期刊介绍: Neuropathology is an international journal sponsored by the Japanese Society of Neuropathology and publishes peer-reviewed original papers dealing with all aspects of human and experimental neuropathology and related fields of research. The Journal aims to promote the international exchange of results and encourages authors from all countries to submit papers in the following categories: Original Articles, Case Reports, Short Communications, Occasional Reviews, Editorials and Letters to the Editor. All articles are peer-reviewed by at least two researchers expert in the field of the submitted paper.
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